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. 2023 Sep 6;18:5075–5093. doi: 10.2147/IJN.S415631

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© 2023 Quiñonero et al.

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In vivo results in NSG mice with PANC-1 induced tumors. Tumor growth (A) and survival of mice (B) after CTRL, NP-ACP-AA, OLA, and NP-ACP-OLA-AA treatments. All the data are represented as mean ± S.D (n= 8–10). **p ≤ 0.01, ***p ≤ 0.001 compared to the control group (CTRL); ^#p ≤ 0.05, ^##p ≤ 0.01, ^###p ≤ 0.001 comparing the tumor growth of OLA and NP-ACP-OLA-AA groups. (C) Histological evaluation of the tumoral tissue using haematoxylin-eosin staining and the penetration of the NPs in the tumoral tissue using alizarin red staining. Scale bar = 500 nm.