Fig. 5.

HSD increased IBD process in vivo. a Schematic diagram of salt concentration on IBD progression. Mice were treated with 2%, 0.9%, and 0% NaCl-H₂O for a week and then fed with 3% DSS, (n = 6). b Mice weight change curve of each group. c Colon length of each group. one mice in 2% NaCl group were dead before the endpoint. d Represent picture of colon tissues of each group. e Schematic diagram of salt change in IBD process. f Mice weight change curve of each group. g Survival curve of each group. h Colon length of each group. i Schematic diagram of post-HSD treatment on IBD process. j Schematic diagram of salt concentration on IBD progression. k Weight change of each mice. l Colon length of DSS and DSS-HSD group. * p < 0.05;** p < 0.01;*** p < 0.001; ****p < 0.0001