Table 2.
Differential metabolites with VIP >1.5 and adjusted p values <0.05
| CRC I vs NI | VIP | p | FDR | FC | log2 (FC) |
|---|---|---|---|---|---|
| C18 | 1.816942 | 1.24E−37 | 2.2E−36 | 11.457 | 3.5182 |
| C16 | 1.801358 | 1.73E−37 | 2.3E−36 | 26.273 | 4.7155 |
| C18:2 | 1.581321 | 1.54E−22 | 9.53E−22 | 4.1326 | 2.047 |
| C4/C3 | 1.546064 | 1.17E−21 | 6.42E−21 | 10.187 | 3.3486 |
| CRC II vs NI | VIP | p | FDR | FC | log2 (FC) |
| Arg/Orn | 1.553826 | 1.39E−20 | 7.61E−20 | 11.674 | 3.5452 |
| Met/Phe | 1.536977 | 1.82E−18 | 8.89E−18 | 2.2877 | 1.1939 |
| C3/C16 | 1.512048 | 1.82E−18 | 8.89E−18 | 22.404 | 4.4857 |
| C4/C3 | 1.594945 | 1.53E−22 | 9.46E−22 | 10.506 | 3.3932 |
| C16 | 1.827176 | 1.84E−36 | 4.27E−35 | 17.096 | 4.0956 |
| C18 | 1.861812 | 1.32E−37 | 4.09E−36 | 10.451 | 3.3855 |
| CRC III vs NI | VIP | p | FDR | FC | log2 (FC) |
| C3/Met | 3.3663041 | 3.09E−33 | 9.59E−32 | 267.67 | 8.0643 |
| (C16 + C18)/C0 | 2.42154 | 1.81E−12 | 4.22E−11 | 2.2815 | 1.19 |
| Cit/Arg | 1.180143 | 0.001409 | 0.009356 | 1.7585 | 0.81434 |
| C10:2 | 1.091316 | 0.001572 | 0.009746 | 1.7133 | 0.77678 |
| C4/C8 | 1.263299 | 0.00056 | 0.004338 | 1.6854 | 0.75312 |
| CRC IV vs NI | VIP | p | FDR | FC | log2 (FC) |
| CO/(C16 + C18) | 2.52033 | 1.09E−22 | 5.07E−21 | 210.4 | 7.717 |
| C4-OH | 1.685166 | 1.53E−09 | 2.04E−08 | 4.6458 | 2.2159 |
| C6DC | 1.509 | 2.06E−06 | 0.0000147 | 2.7299 | 1.4489 |
| CRC III vs CRC I | VIP | p | FDR | FC | log2 (FC) |
| C3/Met | 1.958164 | 5.74E−37 | 5.28E−35 | 213.74 | 7.7397 |
| C0/(C16 + C18) | 1.826395 | 4.31E−30 | 2.35E−28 | 10.218 | 4.7635 |
| C16-OH | 1.879362 | 1.49E−27 | 3.42E−26 | 18.449 | 4.2055 |
| C5/C0 | 1.67155 | 1.54E−16 | 1.01E−15 | 16.821 | 4.0722 |
| C18-OH | 1.810133 | 2.67E−21 | 2.76E−20 | 16.315 | 4.0281 |
| C16-OH/C16 | 1.512287 | 1.62E−13 | 9.33E−13 | 6.853 | 2.7767 |
| Met/Leu | 1.640739 | 7.95E−17 | 5.63E−16 | 4.4459 | 2.1525 |
| C2/C0 | 1.930673 | 5.93E−30 | 2.36E−28 | 4.3378 | 2.117 |
| CRC IV vs CRC I | VIP | p | FDR | FC | log2 (FC) |
| C3/Met | 3.939144 | 7.8E−36 | 7.25E−34 | 208.7 | 7.7053 |
| C0/(C16 + C18) | 2.976943 | 6.21E−12 | 1.93E−10 | 1.9886 | 0.99173 |
| C5DC/C8 | 1.603277 | 0.001918 | 0.022296 | 4.1408 | 2.0499 |
| C2/C0 | 1.595155 | 0.005408 | 0.045719 | 1.2059 | 0.27013 |
| CRC IV vs CRC II | VIP | p | FDR | FC | log2 (FC) |
| C0/(C16 + C18) | 3.67983 | 7.43E−27 | 3.42E−25 | 209.21 | 7.7088 |
| C3/Met | 2.688987 | 9.89E−09 | 2.27E−07 | 2.0737 | 1.0522 |
| C10:2/C10 | 1.912797 | 0.0000603 | 0.000793 | 4.1103 | 2.0392 |
| CRC IV vs CRC III | VIP | p | FDR | FC | log2 (FC) |
| C0/(C16 + C18) | 4.02766 | 9.64E−24 | 4.43E−22 | 191.94 | 7.5845 |
| C3/Met | 2.807645 | 2.27E−08 | 5.22E−07 | 2.0732 | 1.0519 |