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. 2023 Sep 1;73(2):154–160. doi: 10.3164/jcbn.22-130

Fig. 4.

Fig. 4.

Low expression of TMEM189 induced ferroptosis in breast cancer cells. MDA-MB-231 cells were transfected with si-RNA, si-TMEM189, and treated with a certain concentration of Erastin for 24 h. (A) Detection of ROS levels in each group of cells. (B) The level of GSH was detected using a kit. (C) The level of lipid peroxidation was detected using a malondialdehyde (MDA) kit. (D) Western blot was used to tested the protein expression levels of ferroptosis-related factors (COX-2, GPX4, and ACSL4). *p<0.05, #p<0.05.