Fig. 5.

Low expression of TMEM189 inhibited breast cancer development through the ferroptosis pathway. MDA-MB-231 cells were transfected with si-RNA and si-TMEM189, and cells were treated with a certain concentration of ferrostatin-1 for 24 h. (A) Cell viability was measured by CCK-8. (B) The migration ability of cells in each group was detected by wound healing assay. (C) The invasive ability of cells in each group was determined by transwell assay. (D) Protein expression levels of epithelial-mesenchymal transition (EMT)-related proteins (E-cadherin and N-cadherin). *p<0.05, ^#p<0.05.