Figure 7.

Importance of molecular and clinical variables from sepsis screening tools in the prediction cohort. (A) Molecules with highest model-agnostic variable importance by permutation from nested cross-validations of seven different algorithms trained on molecular markers alone. (B) Top-20 model-agnostic variable importance by permutation from nested cross-validations of seven different algorithms trained on all screening tools variables and molecular variables. (C) Pearson correlations between the molecular markers and temperature (*, ** and *** denotes a p-value ˂ 0.05, 0.01 and 0.001 respectively, color denotes correlation coefficient). Molecules labeled with mRNA in parenthesis refers to the gene expression data. Boxplots presented with median and interquartile range (IQR).