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Self-proliferation in the presence of IL-7, IL-15, TGF-β and lipid. (ii) Activation phase: Trm is activated in response to stimulation by IL-23 secreted by DCs. (iii)Onset stage: CD49a−CD8+Trm secretion of IL-17 is involved in psoriasis relapse. IFN-γ secreted by CD49a−CD8+ Trm acts on DCs to form an inflammatory cycle while activating KC. IL-22 secreted by CD4+ Trm recruits inflammatory cells into the superficial dermis to participate in psoriasis relapse.
