FIGURE 2.

Univariable HRs per event and total‐time (blue/dotted) (a) smoking status and (b) pack‐years. Interpretation: Heterogeneity is present for smoking status (Figure 2a) in the direction of the estimate of the effect for the first and consecutive events. Therefore, summary results should be interpreted with caution. Homogeneity in the direction of the estimate of the effect for consecutive events is present for pack‐years (Figure 2b). The broad confidence intervals for the second and third events represent uncertainty caused by smaller risk sets. CI, confidence interval; CRN, colorectal neoplasia; HR, hazard ratio.