Table 4.
Univariate and multivariate Cox regression analysis of OS of EC.
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | P-value | Hazard ratio | 95% CI | P-value | |
| Age (≥60 vs <60) | 1.552 | 1.088-2.215 | 0.015 | 1.082 | 0.748-1.566 | 0.675 |
| BMI | 1.024 | 0.979-1.070 | 0.300 | |||
| FIGO stage | ||||||
| I | ref | <0.001 | ref | 0.012 | ||
| II | 2.563 | 1.349-4.869 | 0.004 | 1.877 | 0.860-4.095 | 0.114 |
| III | 8.921 | 6.159-12.922 | <0.001 | 2.779 | 1.412-5.472 | 0.003 |
|
Pathological type in final pathology
(Type II vs Type I) |
3.117 | 2.233-4.350 | <0.001 | 1.467 | 1.015-2.119 | 0.041 |
|
Myometrial invasion
(≥1/2 vs <1/2) |
3.026 | 2.166-4.229 | <0.001 | 1.562 | 1.078-2.263 | 0.019 |
|
Cervical stromal invasion
(Yes vs No) |
3.003 | 2.109-4.277 | <0.001 | 1.118 | 0.713-1.752 | 0.627 |
|
LVSI
(Positive vs Negative) |
3.136 | 2.248-4.374 | <0.001 | 1.572 | 1.085-2.275 | 0.017 |
|
Lymph node metastasis
(Yes vs No) |
7.551 | 5.408-10.543 | <0.001 | 1.873 | 1.045-3.355 | 0.035 |
|
Adjuvant treatment
(Yes vs No) |
1.230 | 0.865-1.748 | 0.249 | |||
| 4-tier P53 expression | ||||||
| P53wt/P53wt | ref | <0.001 | ref | <0.001 | ||
| P53abn/P53wt | 3.045 | 1.631-5.683 | <0.001 | 2.335 | 1.245-4.381 | 0.008 |
| P53wt/P53abn | 2.504 | 1.386-4.524 | 0.002 | 1.941 | 1.053-3.579 | 0.034 |
| P53abn/P53abn | 4.773 | 3.246-7.018 | <0.001 | 3.386 | 2.254-5.086 | <0.001 |
BMI, body mass index; FIGO, International Federation of Gynecology and Obstetrics; LVSI, lymphatic vessel space invasion; P53wt/P53wt, P53 wild-type in both preoperative biopsy and final pathology; P53abn/P53wt, P53 abnormality in preoperative biopsy while P53 wild-type in final pathology; P53wt/P53abn, P53 wild-type in preoperative biopsy while P53 abnormality in final pathology; P53abn/P53abn, P53 abnormality in both preoperative biopsy and final pathology.