Abstract
The recurrence of isolated neural tube defects in a population of women from a genetic counselling clinic was found to be 3.4%. After one baby with a neural tube defect the recurrence was 2.3%. Of the 15 pregnancies of women who had two previous babies with neural tube defects, there were three further recurrences. These findings show that the Hungarian recurrence risk of isolated neural tube defects has not changed with a declining birth prevalence, and that the rate in genetic counselling clinic patients is the same as in a previous population based epidemiological study.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Carter C. O., Evans K. A., Till K. Spinal dysraphism: genetic relation to neural tube malformations. J Med Genet. 1976 Oct;13(5):343–350. doi: 10.1136/jmg.13.5.343. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carter C. O., Roberts J. A. The risk of recurrence after two children with central-nervous-system malformations. Lancet. 1967 Feb 11;1(7485):306–308. doi: 10.1016/s0140-6736(67)91240-8. [DOI] [PubMed] [Google Scholar]
- Clarke C., Hobson D., McKendrick O. M., Rogers S. C., Sheppard P. M. Spina bifida and anencephaly: miscarriage as possible cause. Br Med J. 1975 Dec 27;4(5999):743–746. doi: 10.1136/bmj.4.5999.743. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Czeizel A., Bognár Z., Rockenbauer M. Some epidemiological data on spontaneous abortion in Hungary, 1971-80. J Epidemiol Community Health. 1984 Jun;38(2):143–148. doi: 10.1136/jech.38.2.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Czeizel A., Kerekes L., Merétey K., Osztovics M., Sobel M., Stuber A., Tarró S. National programme for prevention of the recurrence of neural tube defects. Acta Paediatr Acad Sci Hung. 1979;20(4):315–319. [PubMed] [Google Scholar]
- Czeizel A., Révész C. Major malformations of the central nervous system in Hungary. Br J Prev Soc Med. 1970 Nov;24(4):205–222. doi: 10.1136/jech.24.4.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Czeizel A. Schisis-association. Am J Med Genet. 1981;10(1):25–35. doi: 10.1002/ajmg.1320100105. [DOI] [PubMed] [Google Scholar]
- Danks D. M., Halliday J. L. Incidence of neural tube defects in Victoria, Australia. Lancet. 1983 Jan 1;1(8314-5):65–65. doi: 10.1016/s0140-6736(83)91593-3. [DOI] [PubMed] [Google Scholar]
- Evans D. R. Neural-tube defects: importance of a history of abortion in aetiology. Br Med J. 1979 Apr 14;1(6169):975–976. doi: 10.1136/bmj.1.6169.975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fraser F. C., Czeizel A., Hanson C. Increased frequency of neural tube defects in sibs of children with other malformations. Lancet. 1982 Jul 17;2(8290):144–145. doi: 10.1016/s0140-6736(82)91104-7. [DOI] [PubMed] [Google Scholar]
- Khoury M. J., Erickson J. D., James L. M. Etiologic heterogeneity of neural tube defects: clues from epidemiology. Am J Epidemiol. 1982 Apr;115(4):538–548. doi: 10.1093/oxfordjournals.aje.a113335. [DOI] [PubMed] [Google Scholar]
- Mathers C. D., Field B. Some international trends in the incidence of neural tube defects. Community Health Stud. 1983;7(1):60–66. doi: 10.1111/j.1753-6405.1983.tb00392.x. [DOI] [PubMed] [Google Scholar]
- Nevin N. C., Johnston W. P. A family study of spina bifida and anencephalus in Belfast, Northern Ireland (1964 to 1968). J Med Genet. 1980 Jun;17(3):203–211. doi: 10.1136/jmg.17.3.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Romijn J. A., Treffers P. E. Anencephaly in the Netherlands: a remarkable decline. Lancet. 1983 Jan 1;1(8314-5):64–65. doi: 10.1016/s0140-6736(83)91592-1. [DOI] [PubMed] [Google Scholar]
- Seller M. J. Recurrence risks for neural tube defects in a genetic counseling clinic population. J Med Genet. 1981 Aug;18(4):245–248. doi: 10.1136/jmg.18.4.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stein S. C., Feldman J. G., Friedlander M., Klein R. J. Is myelomeningocele a disappearing disease? Pediatrics. 1982 May;69(5):511–514. [PubMed] [Google Scholar]
- Yen S., MacMahon B. Genetics of anencephaly and spina bifida? Lancet. 1968 Sep 14;2(7568):623–626. doi: 10.1016/s0140-6736(68)90709-5. [DOI] [PubMed] [Google Scholar]