TABLE 3.
Pharmacokinetic parameters of Δ9THC in brain and plasma after inhalation (Exp 1).
| Parameter | Brain | Plasma | ||||
|---|---|---|---|---|---|---|
| Combined a | Male b | Female c | Combined a | Male b | Female c | |
| Dose (mg/kg) | 0.19 | 0.18 | 0.19 | 0.19 | 0.18 | 0.19 |
| C max (ng/mL or ng/g) | 22.0 | 21.2 | 23.2 | 70.4 ± 9.7 d | 82.2 | 47.9 |
| T max (h) | 0.33 | 0.33 | 0.67 | 0.73 ± 0.27 d | 0.17 | 0.67 |
| AUC last (h×ng/mL or h×ng/g) | 44.7 | 47.5 | 41.9 | 120.2 | 123.5 | 121.4 |
| Cl/F (L/h/kg) | - | - | - | 0.7 | 1.2 | 0.3 |
| V z /F(L/kg) | - | - | - | 5.1 | 3.2 | 5.3 |
a
Values represent the average of all samples at each time point (male and female mice).
b
Values represent the average of all male samples at each time point.
c
Values represent the average of all female samples at each time point.
d
Values represent the mean of all samples ±SEM.
Abbreviations: AUClast = area under the plasma concentration-time profile up to the last measurable concentration, Cl = clearance, Cmax = maximum plasma concentration after exposure, Tmax = time to reach Cmax, Vz = volume of distribution, F = bioavailability fraction.