Table 1.
Baseline clinicopathological Characteristics of gastroenteropancreatic neuroendocrine tumors.
| Characteristics | Incidence | Incidence-based mortality | ||||
|---|---|---|---|---|---|---|
| Early-onset | Later-onset | p value | Early-onset | Later-onset | p value | |
| Overall | 17258 (100) | 63323 (100) | 3110 (100) | 26102 (100) | ||
| Age at diagnosis | – | – | ||||
| 0-14 | 327 (1.9) | – | 11 (0.4) | – | ||
| 15-24 | 1414 (8.2) | – | 80 (2.6) | – | ||
| 25-34 | 2963 (17.2) | – | 362 (11.6) | – | ||
| 35-44 | 6617 (38.3) | – | 1267 (40.7) | – | ||
| 45-49 | 5937 (34.4) | – | 1390 (44.7) | – | ||
| Sex | <0.001 | 0.296 | ||||
| Male | 7845 (45.5) | 32280 (51.0) | 1638 (52.7) | 14006 (53.7) | ||
| Female | 9413 (54.5) | 31043 (49.0) | 1472 (47.3) | 12096 (46.3) | ||
| Race | <0.001 | <0.001 | ||||
| White | 12617 (73.1) | 47427 (74.9) | 2337 (75.1) | 20948 (80.3) | ||
| Black | 2586 (15.0) | 9497 (15.0) | 523 (16.8) | 3538 (13.6) | ||
| AI/AN | 161 (0.9) | 393 (0.6) | 30 (1.0) | 144 (0.6) | ||
| AP | 1347 (7.8) | 4663 (7.4) | 213 (6.8) | 1434 (5.5) | ||
| Unknown | 547 (3.2) | 1343 (2.1) | 7 (0.2) | 38 (0.1) | ||
| Marital status | <0.001 | <0.001 | ||||
| Single | 5411 (31.4) | 7774 (12.3) | 883 (28.4) | 2984 (11.4) | ||
| Married | 8732 (50.6) | 35971 (56.8) | 1683 (54.1) | 14411 (55.2) | ||
| Sep/Div/Wid | 1156 (6.7) | 13041 (20.6) | 273 (8.8) | 7113 (27.3) | ||
| Unknown | 1959 (11.4) | 6537 (10.3) | 271 (8.7) | 1594 (6.1) | ||
| Grade | <0.001 | <0.001 | ||||
| I | 5367 (31.1) | 17722 (28.0) | 445 (14.3) | 4373 (16.8) | ||
| II | 1229 (7.1) | 4478 (7.1) | 237 (7.6) | 1707 (6.5) | ||
| III+IV | 675 (3.9) | 4421 (7.0) | 502 (16.1) | 3729 (14.3) | ||
| Unknown | 9987 (57.9) | 36702 (58.0) | 1926 (61.9) | 16293 (62.4) | ||
| Stage | <0.001 | <0.001 | ||||
| Localized | 9527 (55.2) | 29563 (46.7) | 555 (17.8) | 6988 (26.8) | ||
| Regional | 2785 (16.1) | 11885 (18.8) | 426 (13.7) | 4688 (18.0) | ||
| Distant | 2228 (12.9) | 11744 (18.5) | 1282 (41.2) | 8241 (31.6) | ||
| Unknown | 2718 (15.7) | 10131 (16.0) | 847 (27.2) | 6185 (23.7) | ||
| Surgery | <0.001 | <0.001 | ||||
| Yes | 14071 (81.5) | 46420 (73.3) | 1891 (60.8) | 16622 (63.7) | ||
| No | 2978 (17.3) | 16134 (25.5) | 1168 (37.6) | 9186 (35.2) | ||
| Unknown | 209 (1.2) | 769 (1.2) | 51 (1.6) | 294 (1.1) | ||
| Chemotherapy | 0.005 | <0.001 | ||||
| Yes | 1649 (9.6) | 6516 (10.3) | 1097 (35.2) | 4808 (18.4) | ||
| No/Unknown | 15609 (90.4) | 56807 (89.7) | 2013 (64.7) | 21294 (81.6) | ||
| Radiation | 0.043 | <0.001 | ||||
| Yes | 342 (2.0) | 1416 (2.2) | 225 (7.2) | 1071 (4.1) | ||
| No/Unknown | 16916 (98.0) | 61907 (97.8) | 2885 (92.8) | 25031 (95.9) | ||
| Primary sites | <0.001 | <0.001 | ||||
| Appendix | 4358 (25.3) | 4053 (6.4) | 329 (10.6) | 1180 (4.5) | ||
| Colon | 1018 (5.9) | 6436 (10.2) | 366 (11.8) | 3872 (14.8) | ||
| Rectum | 4683 (27.1) | 16078 (25.4) | 471 (15.1) | 3762 (14.4) | ||
| Small intestine | 2989 (17.3) | 19376 (30.6) | 615 (19.8) | 8968 (34.3) | ||
| Stomach | 1425 (8.3) | 6568 (10.4) | 270 (8.7) | 2912 (11.2) | ||
| Pancreas | 2785 (16.1) | 10812 (17.1) | 1059 (34.1) | 5408 (20.7) | ||
AI/AN, American Indian/Alaska Native; AP, Asian or Pacific Islander; Sep/Div/Wid, Separated/Divorced/Widowed.