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. 2023 Aug 3;15(9):e17376. doi: 10.15252/emmm.202317376

Figure 4. SARS‐CoV‐2 MA10‐infected BABLB/c mice at 48 h follow‐up (N = 16 mice).

Figure 4

  • A–G
    PEGSerp‐1 treatment reduced lung consolidation and iNOS + macrophage infiltration. iNOS M1‐stained macrophage invasion in saline control‐treated mice (A) is significantly reduced with PEGSerp‐1 treatment (B). Graphs illustrate significant reductions in mean iNOS‐positive M1 macrophage (C; *P < 0.05) and F4/80 macrophage (D; *P < 0.012)‐positive stained cell counts. H & E‐stained histology sections of lung illustrating consolidation in saline‐treated mice (E) is reduced by PEGSerp‐1 treatment (F). Graph of measured consolidation area divided by total lung area (G; P = 0.1073). PEGSerp‐1‐treated and saline‐treated uninfected mouse tissues had similar levels of inflammation and consolidation (E, G). Mean for positively stained cell counts in three high‐power fields (HPF) per mouse. Black arrows point to brown iNOS‐positive macrophage on IHC‐stained lung sections (Mag 40×).

Data information: (Mean ± SE; *P < 0.05; ANOVA indicated by line at top with subgroup analyses in brackets below; back and blue circles—saline, red and green circles—PEGSerp‐1 treatments).

Source data are available online for this figure.