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. 2023 Aug 3;15(9):e17399. doi: 10.15252/emmm.202317399

Figure EV1. Characterization of the TAZG197V mouse model.

Figure EV1

  • A
    Presentation of Crispr/Cas9 generated mutation in Exon 7 in the gene encoding Tafazzin.
  • B
    Western blot analysis of steady state protein levels from isolated heart mitochondria of 20‐week‐old female TAZG197V heterozygous mice.
  • C
    Body weight of female WT and TAZG197V heterozygous mice. Mean ± SEM, n = 8, 2Way ANOVA Multiple comparisons: *P < 0.05.
  • D
    Steady state protein levels analyzed by western blotting of isolated mitochondria from brain, liver, and muscle of 12‐week‐old male mice.
  • E–J
    Quantification of stroke volume (E), cardiac output from parasternal short axis (SAX) (F), left ventricle posterior systolic wall thickness analyzed from parasternal short axis (SAX) (G), Radial systolic strain (H) Circumferential systolic strain (I), And longitudinal diastolic strain (J). Mean ± SEM, n = 9, 2Way ANOVA Multiple comparisons: *P < 0.05, **P < 0.01, ****P < 0.0001.