Fig. 2.

Tumor response assessment based on RECIST v1.1 per independent review. (A) Waterfall plot of change from baseline in tumor size (n = 38). Baseline was defined as the last measurement taken before the randomisation date. For each patient, the best (minimum) percentage change from baseline in the sum of diameters for all target lesions was represented by a vertical line, plotted in order of greatest percentage increase to greatest percentage decrease. Only patients with measurable disease at baseline and at least one post-baseline assessment were included in the waterfall plots. (B) Spider plot of the longitudinal change from baseline in tumor size (n = 38). The blue line represents responder; yellow line represents non-responder. (C) Swimmer plot on treatment exposure and response duration (n = 38).