Table 1.
Age-specific reference values for TyG and SPISE index in children and adults.
| Age groups (years) | N | P2.5 (CI 90%) | P5 (CI 90%) | P10 (CI 90%) | P25 (CI 90%) | P50 (CI 90%) | P75 (CI 90%) | P90 (CI 90%) | P95 (CI 90%) | P97.5 (CI 90%) |
|---|---|---|---|---|---|---|---|---|---|---|
| TyG index | ||||||||||
| 5–8 | 436 | 3.9 (3.8–3.9) | 3.9 (3.9–3.9) | 4.0 (3.9–4.0) | 4.1 (4.0–4.1) | 4.2 (4.2–4.2) | 4.3 (4.3–4.3) | 4.5 (4.4–4.5) | 4.6 (4.6–4.7) | 4.7 (4.6–4.8) |
| 9–10 | 446 | 3.9 (3.8–3.9) | 3.9 (3.9–4.0) | 4.0 (4.0–4.0) | 4.1 (4.1–4.1) | 4.3 (4.3–4.3) | 4.4 (4.4–4.5) | 4.6 (4.6–4.7) | 4.8 (4.7–4.9) | 4.9 (4.9–5) |
| 11–15 | 888 | 4.0 (3.9–4.0) | 4.0 (4.0–4.0) | 4.1 (4.1–4.1) | 4.2 (4.2–4.2) | 4.3 (4.3–4.3) | 4.5 (4.5–4.5) | 4.7 (4.6–4.7) | 4.8 (4.7–4.8) | 4.8 (4.8–4.9) |
| 16–23 | 324 | 4.0 (3.9–4.0) | 4.0 (4.0–4.1) | 4.1 (4.1–4.1) | 4.2 (4.2–4.3) | 4.4 (4.4–4.4) | 4.5 (4.5–4.6) | 4.7 (4.6–4.7) | 4.8 (4.7–4.8) | 4.8 (4.8–4.9) |
| 24–59 | 2644 | 4.1 (4.1–4.1) | 4.1 (4.1–4.2) | 4.2 (4.2–4.2) | 4.3 (4.3–4.3) | 4.5 (4.5–4.5) | 4.7 (4.7–4.7) | 4.9 (4.9–4.9) | 5.0 (5.0–5.0) | 5.1 (5.1–5.1) |
| 60–80 | 1047 | 4.2 (4.2–4.2) | 4.3 (4.2–4.3) | 4.3 (4.3–4.3) | 4.4 (4.4–4.4) | 4.6 (4.6–4.6) | 4.7 (4.7–4.7) | 4.9 (4.8–4.9) | 5.0 (4.9–5.0) | 5.0 (5.0–5.1) |
| SPISE index | ||||||||||
| 5–8 | 444 | 8.7 (8.1–9.1) | 9.8 (9.3–10.3) | 11.0 (10.6–11.6) | 13.0 (12.6–13.4) | 14.8 (14.5–15.1) | 16.4 (16.2–16.6) | 18.0 (17.7–18.4) | 18.7 (18.5–19.1) | 19.2 (18.9–19.5) |
| 9–10 | 449 | 6.8 (6.4–6.9) | 7.4 (7.0–7.8) | 8.2 (7.9–8.4) | 10.8 (10.4–11.3) | 12.8 (12.6–13.0) | 14.9 (14.6–15.3) | 16.6 (16.1–17.0) | 17.6 (17.3–17.9) | 18.2 (17.9–18.6) |
| 11–15 | 896 | 6.1 (6.0–6.3) | 6.3 (6.1–6.5) | 7.0 (6.8–7.2) | 8.4 (8.2–8.5) | 10.2 (10.0–10.4) | 12.2 (12.0–12.4) | 14.1 (13.7–14.3) | 15.5 (15.4–16.0) | 16.2 (15.6–16.6) |
| 16–23 | 322 | 5.6 (5.3–6.1) | 5.9 (5.6–6.0) | 6.4 (6.0–6.5) | 7.6 (7.3–7.8) | 9.2 (8.9–9.5) | 10.3 (10.1–10.4) | 11.6 (11.4–12.1) | 12.2 (11.9–12.6) | 12.8 (12.5–13.3) |
| 24–59 | 2658 | 4.6 (4.5–4.7) | 4.9 (4.8–5.0) | 5.3 (5.3–5.4) | 6.1 (6.0–6.2) | 7.2 (7.2–7.3) | 8.7 (8.5–8.7) | 10.0 (10.0–10.2) | 10.8 (10.7–10.9) | 11.5 (11.2–11.6) |
| 60–80 | 1047 | 4.7 (4.6–4.8) | 5.0 (4.9–5.0) | 5.3 (5.2–5.4) | 5.9 (5.8–6.0) | 6.7 (6.6–6.8) | 7.7 (7.6–7.8) | 8.9 (8.8–9.0) | 9.5 (9.3–9.6) | 10.2 (10.0–10.7) |
Reference ranges were determined non-parametrically.
CI, confidence interval; N, number of subjects (multiple measurements of one subject within the same age group were randomly excluded); P, percentile; TyG index, triglyceride glucose index (Ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)]/2); SPISE index, single-point insulin sensitivity estimator index (600 × HDL-C (mg/dL)0.185/[TG (mg/dL)0.2 × BMI (kg/m2)1.338]).