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. 2023 Aug 28;14:1250559. doi: 10.3389/fimmu.2023.1250559

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Copyright © 2023 Mabbitt, Holyer, Roper, Nilsson, Zetterberg, Vuong, Mackinnon, Pedersen and Slack

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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post-hocLLC1 subcutaneous tumor digests were analysed for tumor infiltrating CD8+ T cell populations by flow cytometry. Frequency of (A) CD3+, (C) CD4+ and (E) CD8+ cells expressed as a % of the total immune (CD45+) population and Ki-67 expression as mean fluorescence intensity (MFI) in (B) CD3+, (D) CD4+ and (F) CD8+ T cells. Results are expressed as mean ± SEM (vehicle n=12, GB1211 n=10, anti-PD-L1 n=10, GB1211+anti-PD-L1 n=12). Analysed via one-way ANOVA with Dunnett’s post-test with only significant changes shown except for drug combination p-value shown in panel 4 (E).