Table 4.

Comparison of CARS results before and after transcranial pulse stimulation treatment and 1- and 3-month follow-ups (cont’d)

CARS items		3-month follow-up		1-month follow-up		After TPS		Before TPS		Before versus after TPS	Before versus 1 month	Before versus 3 months
		n = 16	%	n = 16	%	n = 16	%	n = 16	%	P	P	P
Taste, smell and touch response and use										0.069	0.044*	0.034*
	Normal	8	50.0	11	68.8	7	43.8	6	37.5
	Mild	7	43.8	3	18.8	7	43.8	3	18.8
	Moderate	1	6.3	2	12.5	2	12.5	6	37.5
	Severe	0	0	0	0	0	0	1	6.3
Fear or nervousness										0.002**	0.005**	0.002**
	Normal	8	50.0	7	43.8	9	56.3	2	12.5
	Mild	6	37.5	7	43.8	5	31.3	7	43.8
	Moderate	2	12.5	2	12.5	2	12.5	4	25.0
	Severe	0	0	0	0	0	0	3	18.8
Verbal communication										<0.001***	0.003**	<0.001***
	Normal	6	37.5	4	25.0	7	43.8	1	6.3
	Mild	9	56.3	11	68.8	9	56.3	6	37.5
	Moderate	1	6.3	1	6.3	0	0	9	56.3
	Severe	0	0	0	0	0	0	0	0
Non-verbal communication										0.069	0.048*	0.045*
	Normal	7	43.8	6	37.5	5	31.3	3	18.8
	Mild	8	50.0	8	50.0	10	62.5	8	50.0
	Moderate	1	6.3	2	12.5	1	6.3	4	25.0
	Severe	0	0	0	0	0	0	1	6.3
Activity level										0.669	0.751	1.00
	Normal	8	50.0	8	50.0	9	56.3	8	50.0
	Mild	5	31.3	6	37.5	4	25.0	5	31.3
	Moderate	3	18.8	2	12.5	3	18.8	3	18.8
	Severe	0	0	0	0	0	0	0	0
Level and consistency of intellectual response										0.015*	0.048*	0.173
	Normal	8	50.0	9	56.3	9	56.3	6	37.5
	Mild	6	37.5	6	37.5	7	43.8	5	31.3
	Moderate	2	12.5	1	6.3	0	0	5	31.3
	Severe	0	0	0	0	0	0	0	0
General impression										0.002**	0.015*	0.020*
	Normal	7	43.8	11	68.8	10	62.5	5	31.3
	Mild	9	56.3	4	25.0	6	37.5	8	50.0
	Moderate	0	0	1	6.3	0	0	3	18.8
	Severe	0	0	0	0	0	0	0	0
Total CARS score	Mean (SD)	23.56 (6.50)		23.44 (7.12)		23.44 (5.66)		30.81 (5.91)		<0.001***	0.002**	<0.001***

CARS, Childhood Autism Rating Scale; SD, standard deviation; TPS, transcranial pulse stimulation.

*P < 0.05; **P < 0.01; ***P < 0.001.