Table 1.
Demographical features, stimulation parameters and clinical assessments of Parkinson’s disease patients with FOG
| Parkinson’s disease-FOG patients | |||
|---|---|---|---|
| Pre-op assessment | Post-op assessment | P-value | |
| Demographical features | |||
| Gender (male:female) | 39:37 | ||
| Age at onset (years) | 52.45 ± 9.82 | ||
| Disease duration (years) | 9.79 ± 4.22 | ||
| Age at surgery (years) | 62.40 ± 8.66 | ||
| MDS-UPDRS III levodopa response (%) | 57.29 ± 18.35 | ||
| Clinical assessments | |||
| Follow-up (months) | 12.14 ± 7.03 | ||
| Hoehn–Yahr stage (1/1.5/2/2.5/3/4/5) | 0/1/3/11/46/11/4 | 3/10/22/18/14/6/3 | |
| LEDD (mg/day) | 941.41 ± 372.74 | 629.53 ± 252.3 | <0.001 |
| FOG-Q | 16.89 ± 5.46 | 10.05 ± 7.16 | <0.001 |
| MDS-UPDRS I | 17.36 ± 7.23 | 11.64 ± 5.16 | <0.001 |
| MDS-UPDRS II | 21.16 ± 7.89 | 11.68 ± 6.73 | <0.001 |
| MDS-UPDRS III (med-off) | 51.05 ± 19.75 | 22.8 ± 13.42 | <0.001 |
| MDS-UPDRS III (med-on) | 22.32 ± 13.85 | 11.06 ± 6.82 | <0.001 |
| MDS-UPDRS IV | 10.66 ± 6.64 | 5.6 ± 3.53 | <0.001 |
| Berg balance scale (med-off) | 35.87 ± 13.62 | 46.79 ± 10.26 | <0.001 |
| Berg balance scale (med-on) | 47.17 ± 9.54 | 51.54 ± 6.28 | <0.001 |
| MMSE | 26.11 ± 3.12 | 26.91 ± 3.53 | 0.091 |
| MoCA score | 22.61 ± 3.77 | 22.96 ± 4.00 | 0.416 |
| HAM-D score | 17.79 ± 8.02 | 13.17 ± 8.19 | 0.003 |
| HAM-A score | 19.08 ± 8.51 | 12.87 ± 8.23 | <0.001 |
| PDQ-39 | 66.18 ± 22.2 | 44.57 ± 26.9 | <0.001 |
| Stimulation parameters | |||
| Right-side versus left-side amplitude (Hz) | 2.36 ± 0.56 versus 2.41 ± 0.52 | 0.602 | |
| Right-side versus left-side pulse width (μs) | 67.63 ± 11.30 versus 70.00 ± 11.43 | 0.204 | |
| Right-side versus left-side frequency (V) | 131.34 ± 21.24 versus 130.88 ± 19.86 | 0.926 | |
DBS, deep brain stimulation; Med, medication; pre-op, pre-operative; post-op, post-operative; PSQ-39, Parkinson’s disease questionnaire. Significant differences are bold typed.