Comparison 4. RISPERIDONE DEPOT vs ORAL QUETIAPINE.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Leaving the study early: 1. Any reason	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 long term	1	666	Risk Ratio (M‐H, Random, 95% CI)	0.84 [0.74, 0.95]
2 Leaving the study early: 2. Specific	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 due to relapse ‐ long term	1	666	Risk Ratio (M‐H, Random, 95% CI)	0.54 [0.40, 0.73]
3 Adverse events: 1. General	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 any	1	666	Risk Ratio (M‐H, Random, 95% CI)	0.98 [0.89, 1.09]
3.2 serious	1	666	Risk Ratio (M‐H, Random, 95% CI)	0.84 [0.62, 1.13]
3.3 death	1	666	Risk Ratio (M‐H, Random, 95% CI)	1.54 [0.26, 9.14]
4 Adverse events: 2. Specifc	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 psychiatric symptoms	1	666	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.84, 1.19]
4.2 prolactin related	1	666	Risk Ratio (M‐H, Random, 95% CI)	3.07 [1.13, 8.36]
4.3 hyperprolactinaemia	1	666	Risk Ratio (M‐H, Random, 95% CI)	8.81 [3.53, 21.96]
4.4 serious psychiatric symptoms	1	666	Risk Ratio (M‐H, Random, 95% CI)	0.82 [0.58, 1.16]
4.5 weight increase	1	666	Risk Ratio (M‐H, Random, 95% CI)	1.12 [0.63, 1.99]
4.6 headache	1	666	Risk Ratio (M‐H, Random, 95% CI)	1.21 [0.64, 2.26]
4.7 fatigue/somnolence	1	666	Risk Ratio (M‐H, Random, 95% CI)	0.16 [0.07, 0.38]
5 Adverse events: 2. Specific: Mean (SD) weight increase in kg	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
5.1 long term	1	666	Mean Difference (IV, Random, 95% CI)	1.25 [0.25, 2.25]
6 Adverse events: 3. Movement disorder	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
6.1 any extra pyramidal symptom	1	666	Risk Ratio (M‐H, Random, 95% CI)	1.83 [1.07, 3.15]
6.2 tremor	1	666	Risk Ratio (M‐H, Random, 95% CI)	5.12 [1.13, 23.20]
6.3 tardive dyskinesia	1	666	Risk Ratio (M‐H, Random, 95% CI)	0.34 [0.04, 3.27]
6.4 dystonia	1	666	Risk Ratio (M‐H, Random, 95% CI)	0.51 [0.05, 5.62]
6.5 parkinsonism	1	666	Risk Ratio (M‐H, Random, 95% CI)	2.56 [1.01, 6.52]
6.6 hyperkinesia	1	666	Risk Ratio (M‐H, Random, 95% CI)	1.66 [0.70, 3.96]