Comparison 7. RISPERIDONE DEPOT vs ALL ORAL ANTIPSYCHOTICS (PRIMARY OUTCOMES).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Global state: 1. Relapse (any reason)	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 vs aripiprazole ‐ long term	1	349	Risk Ratio (M‐H, Random, 95% CI)	1.05 [0.83, 1.33]
1.2 vs general oral antipsychotics ‐ long term	1	63	Risk Ratio (M‐H, Random, 95% CI)	2.13 [0.84, 5.43]
2 Mental state: 1. Average change scores (PANSS, high score = worse) 1. total	4		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.1 vs oral risperidone (non ITT data) ‐ short term	2	591	Mean Difference (IV, Random, 95% CI)	1.05 [‐0.77, 2.88]
2.2 vs olanzapine ‐ short term	1	377	Mean Difference (IV, Random, 95% CI)	0.90 [‐2.25, 4.05]
2.3 vs olanzapine ‐ long term	1	361	Mean Difference (IV, Random, 95% CI)	0.10 [‐3.96, 4.16]
2.4 vs aripiprazole ‐ long term	1	349	Mean Difference (IV, Random, 95% CI)	‐0.10 [‐3.15, 2.95]
3 Leaving the study early: 1. Any reason	7		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 vs aripiprazole	2	723	Risk Ratio (M‐H, Random, 95% CI)	0.83 [0.53, 1.30]
3.2 vs quetiapine	1	666	Risk Ratio (M‐H, Random, 95% CI)	0.84 [0.74, 0.95]
3.3 vs oral risperidone	2	690	Risk Ratio (M‐H, Random, 95% CI)	1.28 [0.92, 1.79]
3.4 vs any new generation antipsychotic	1	77	Risk Ratio (M‐H, Random, 95% CI)	0.72 [0.55, 0.95]
3.5 vs olanzapine	1	618	Risk Ratio (M‐H, Random, 95% CI)	1.32 [1.10, 1.58]
3.6 vs any oral antipsychotic	1	382	Risk Ratio (M‐H, Random, 95% CI)	1.25 [0.93, 1.68]
4 Adverse events: 1. Death	5		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 vs olanzapine	1	618	Risk Ratio (M‐H, Random, 95% CI)	0.31 [0.06, 1.55]
4.2 vs oral risperidone	1	640	Risk Ratio (M‐H, Random, 95% CI)	0.34 [0.01, 8.20]
4.3 vs any oral antipsychotic	1	382	Risk Ratio (M‐H, Random, 95% CI)	1.01 [0.14, 7.10]
4.4 vs aripiprazole	2	729	Risk Ratio (M‐H, Random, 95% CI)	0.98 [0.13, 7.36]
4.5 vs quetiapine	1	666	Risk Ratio (M‐H, Random, 95% CI)	1.54 [0.26, 9.14]
5 Adverse events: 1. General: a. any	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
5.1 vs aripiprazole	2	729	Risk Ratio (M‐H, Random, 95% CI)	0.99 [0.87, 1.14]
5.2 vs oral risperidone	1	640	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.91, 1.18]
5.3 vs quetiapine	1	666	Risk Ratio (M‐H, Random, 95% CI)	0.98 [0.89, 1.09]
6 Adverse events: 1. General: b. serious	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
6.1 vs quetiapine	1	666	Risk Ratio (M‐H, Random, 95% CI)	0.84 [0.62, 1.13]
6.2 vs aripiprazole	2	729	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.66, 1.39]
6.3 vs olanzapine	1	547	Risk Ratio (M‐H, Random, 95% CI)	1.10 [0.80, 1.51]
7 Adverse events: 2. Movement disorder: a. any extra pyramidal symptoms	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
7.1 vs aripiprazole	2	729	Risk Ratio (M‐H, Random, 95% CI)	1.19 [0.91, 1.55]
7.2 vs quetiapine	1	666	Risk Ratio (M‐H, Random, 95% CI)	1.83 [1.07, 3.15]
7.3 vs olanzapine	1	547	Risk Ratio (M‐H, Random, 95% CI)	1.67 [1.19, 2.36]
7.4 vs oral risperidone	1	640	Risk Ratio (M‐H, Random, 95% CI)	1.05 [0.59, 1.88]