Figure 1. Flow of Participants Through Target-HTN.

Cohort 1: plasma renin activity (PRA) ≤1.0 ng/mL/h; cohort 2: PRA >1.0 ng/mL/h. See Statistical Analysis for definitions of intercurrent event types and Results for a summary of participants in each group with each type.

^aSeven participants were inadvertently screened following prescreening failure and did not participate in run-in.

^bOther reasons included not meeting blood pressure criteria at screening visit; not meeting laboratory entry criteria, such as patients with hyperkalemia, decreased estimated glomerular filtration rate, or low serum cortisol; exclusionary medical conditions; or current use of exclusionary medications.