Table 1.
Timeline flowchart of the blood withdrawal for the study with epidemiological data source and vaccination plan reference.
| Visit |
1st Visit (T0) |
2nd Visit (T1) |
3 d Visit (T2) |
|---|---|---|---|
| Baseline |
+3 months |
+6 months |
|
| April–June 2021 (Alpha/Delta SARS CoV-2 Waves)a | From July to September 2021 | Until December 2021 | |
| Inclusion/exclusion checkb | • | ||
| Written informed consent | • | ||
| Pre-vaccination blood for serum sampling (5 mL) | • | ||
| BNT162b2 vaccinationc | • | • | |
| Post-vaccination blood for serum sampling (5 mL) | • | • |
a
Data source: https://www.covid19.admin.ch/en/epidemiologic/virus-variants?variantZoomMonitoringSeg=2022-01-02_2022-04-03.
b
Subjects with previous Sars-Cov-2 infection or symptoms or positive PCR test in the 3 months before T0 were excluded from the study following vaccination medical recommendation in effect at that time (Strategie-de-vaccination-COVID-19-OFSP-EKIF.pdf (bag-coronavirus.ch).
c
Subjects followed the vaccination plan established by: https://www.who.int/news-room/feature-stories/detail/who-can-take-the-pfizer-biontech-covid-19--vaccine-what-you-need-to-know.