Table 2.
Number, frequency and odds ratio for comorbid conditions of patients with lichen sclerosus compared to controls
| Comorbidity | ICD-10-code | Lichen sclerosus (n = 5680) n (%) | OR (95% CI) | Adjusted OR c (95% CI) | Significance leveld |
|---|---|---|---|---|---|
| Leukoplakia of vulvaa | N90.4 | 525 (9.2) | 463.6 (354.2–606.9) | 361.1 (274.8–474.6) | *** |
| Leukoplakia of penisb | N48.0 | 351 (6.2) | 3.3 (3.0–3.8) | 3.3 (2.9–3.7) | *** |
| Malignant tumor of penisb | C60 | 11 (0.2) | 11.6 (5.6–24.1) | 9.1 (4.3–18.9) | *** |
| Malignant tumor of prostateb | C61 | 112 (2.0) | 2.4 (2.0–2.9) | 2.0 (1.6–2.4) | *** |
| Malignant tumor of testicleb | C62 | 2 (0.0) | 0.8 (0.2–3.1) | 0.7 (0.2–2.9) | ns |
| Malignant tumor of urethra | C68 | 1 (0.0) | 3.5 (0.5–26.6) | 3.1 (0.4–23.5) | ns |
| Malignant tumor of vulvaa | C51 | 47 (0.8) | 29.1 (20.2–41.9) | 17.4 (12.1–25.3) | *** |
| Malignant tumor of breast | C50 | 228 (4.0) | 3.7 (3.3–4.3) | 1.6 (1.4–1.8) | *** |
| Alopecia areata | L63 | 53 (0.9) | 2.4 (1.8–3.2) | 2.2 (1.6–2.9) | *** |
| Ulcerative colitis | K51 | 89 (1.6) | 2.1 (1.7–2.6) | 1.8 (1.5–2.2) | *** |
| Crohn´s disease | K50 | 62 (1.1) | 2.4 (1.8–3.1) | 2.0 (1.6–2.6) | *** |
| Diabetes mellitus type 1 | E10 | 208 (3.7) | 2.4 (2.1–2.8) | 1.9 (1.6–2.1) | *** |
| Localized scleroderma (morphea) | L94 | 31 (0.5) | 10.3 (7.0–15.0) | 6.9 (4.7–10.2) | *** |
| Systemic sclerosis | M34 | 11 (0.2) | 7.1 (3.8–13.3) | 4.2 (2.2–7.8) | *** |
| Thyroiditis | E06 | 31 (0.5) | 1.6 (1.1–2.2) | 1.1 (0.7–1.5) | ns |
| Thyrotoxicosis (Grave´s disease) | E05 | 127 (2.2) | 2.3 (1.9–2.8) | 1.3 (1.1–1.6) | ** |
| Myasthenia gravis | G70 | 6 (0.1) | 2.7 (1.2–6.0) | 1.8 (0.8–4.0) | ns |
| Multiple sclerosis | G35 | 13 (0.2) | 1.1 (0.6–1.9) | 0.7 (0.4–1.3) | ns |
| Guillain-Barré syndrome | G61 | 7 (0.1) | 2.1 (1.0–4.4) | 1.6 (0.7–3.4) | ns |
| Vitiligo | L80 | 52 (0.9) | 3.0 (2.3–4.0) | 2.8 (2.1–3.7) | *** |
| Systemic lupus erythematosus | M32 | 17 (0.3) | 3.5 (2.1–5.6) | 2.1 (1.3–3.4) | ** |
| Vasculitis | L95 | 34 (0.6) | 5.7 (4.0–8.2) | 3.9 (2.7–5.6) | *** |
| Lichen ruber planus | L43 | 198 (3.5) | 11.1 (9.5–12.9) | 7.9 (6.8–9.2) | *** |
| Lyme disease | A69.2 | 478 (8.4) | 1.7 (1.6–1.9) | 1.3 (1.2–1.4) | *** |
| Seropositive rheumatoid arthritis | M05 | 56 (1.0) | 2.2 (1.7–2.8) | 1.2 (0.9–1.5) | ns |
| Other rheumatoid arthritis | M06 | 127 (2.2) | 2.8 (2.3–3.3) | 1.6 (1.3–1.9) | *** |
| Polyarteritis nodosa | M30 | 5 (0.1) | 3.3 (1.3–8.1) | 3.1 (1.2–7.6) | * |
| Other necrotizing vasculopathies | M31 | 37 (0.7) | 3.2 (2.3–4.5) | 1.9 (1.3–2.6) | *** |
aOnly females were included in regression analysis
bOnly males were included in regression analysis
cOdds ratio adjusted for age group and sex, if both sexes were included in regression analysis
dSignificance level of adjusted odds ratio
(* p<0.05; ** p<0.01; *** p<0.001; ns p>0.05)