Table 3.
Binding affinities, polar bonds, and hydrophobic interactions of phytochemicals (1-4) with XO.
Compound | Affinity (kcal/mol) | Polar bonds | Hydrophobic interactions |
---|---|---|---|
1 | −8.6 | His741, Phe742 and Gln1194 | His579, Leu744, Phe798, Gly1039, Gly1193, Val1200, Ile1229 and Ile1235 |
2 | −9.8 | Tyr592, His741 and Phe742 | Gln585, Leu744, Phe798 Gly795, Gly1039, Gly1193 Gln1194, Gly1197, Val1200, Gln1201 and Ile1229 |
3 | −8.6 | Gln585, Leu744, Gly795, Phe798, Gly1197, Val1200, Gln1201, Ile1229 and Pro1230 | |
4 | −8.2 | Gly1197 | Phe742, Leu744, Gly795, Phe798, Val1200, Gln1201, Ile1229 and Pro1230 |