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. 2023 Sep 11;220(11):e20230106. doi: 10.1084/jem.20230106

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© 2023 Moniruzzaman et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 2. — Endogenous IL-22 suppresses epithelial MHC II. (A and B) Flow cytometry plots of relative frequency, MFI of total MHC II expression, and absolute Epcam^+ve and Epcam^+ve MHCII^+ve counts in lung (A) and colonic (B) epithelial cells isolated from naïve Il22ra1 fl/fl (Il22ra1^WT) and CMV-cre × Il-22ra1 fl/fl (Il22ra1^KO) mice. (C and E) Representative pathology (H&E) and MHC II expression and quantitation (pixels/mm²) in the lungs (C) and intestine (E) of Il22ra1^WT and Il22ra1^KO animals. (D and F) mRNA levels of Ifng in the lung (D) and intestine (F) in the of Il22ra1^WT and Il22ra1^KO animals. Statistics: mean ± SEM (n = 5–9); data are representative of two independent experiments. t test; *P < 0.05, **P < 0.01, and ****P < 0.0001.