FIG. 4.

Correlation between FAC region weights and BC of regions. The region weights of regions on FAC are plotted on x-axis, whereas the normalized difference in BC between AD and NL networks is plotted on y-axis. The regions are delineated by using AAL. The regions shown by red circles are identified as hypermetabolic on the AD metabolic pattern, whereas the ones shown in blue are identified as hypometabolic on FAC. The regions denoted by green circles are the ones that do not undergo significant metabolic change in AD. A significant correlation (r = 0.254, p < 0.005), shown by a solid black line, exists between region weights of regions on FAC and their corresponding BC values. BC, betweenness centrality.