Table 6.
The Effects of a Topical Ointment Made from Solvent Fractions of P. africana Stem Bark on Wound Contraction in a Mouse Excision Wound Model
| Group | Wound Area in mm2 (Values in Parenthesis Represent the Percentage of Wound Closure) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Day 2 | Day 4 | Day 6 | Day 8 | Day 10 | Day 12 | Day 14 | Day 16 | Day 18 | |
| SO | 304.38±1.5 (3.06) | 270.13±2.23 (13.97) | 222.45±1.76 (29.15) | 169.3±2.93 (46.08) | 104.82±2.98 (66.61) | 62.54±5.25 (80.08) | 41.38±1.95 (86.82) | 24.43±1.45 (92.21) | 12.44±0.96 (96.03) |
| 0.2%NF | 293.95±3.01 (6.38) | 245.9±2.23 (21.68)a,B,b,B | 161.18±13.75 (48.66)a,A,b,A,c,B | 86.05±2.04 (72.59)a,A,b,A,c,A | 49.19±2.87 (84.33)a,A,b,A,c,A | 21.31±1.27 (93.21)a,A,b,A,c,A | 5.9±0.46 (98.12)a,A,b,A,c,A | 0 (100)a,A,b,A,c,A | – |
| 5% AF | 298.25±2.09 (5.01) | 249.69±2.94 (20.48)a,B,b,C | 165.17±4.22 (47.39)a,A,b,B,c,B | 99.33±4.75 (68.36)a,A,b,B,c,B | 58.94±3.28 (81.22)a,A,b,B,c,C | 30.09±3.12 (90.41)a,A,b,C,c,C | 12.39±1.21 (96.05)a,A,b,A,c,A | 3.86±0.88 (98.77)a,A,b,A,c,A | 0 (100)a,A,b,A,c,A |
| 10% AF | 295.99±3.25 (5.73) | 247.38±3.5 (21.21)a,B,b,C | 158.44±7.96 (49.54)a,A,b,A,c,A | 84.53±9.22 (73.07)a,A,b,A,c,A | 46.61±6.07 (85.15)a,A,b,A,c,A | 22±3.88 (92.99)a,A,b,A,c,A | 8.45±1.69 (97.3)a,A,b,A,c,A | 0 (100)a,A,b,A,c,A | – |
| 5% BF | 297.23±2.02 (5.34) | 252.11±5.22 (19.71)a,C | 175.81±7.06 (44)a,B,b,C,c,C | 101.54±5.84 (67.66)a,A,b,B,c,C | 60.72±5.34 (80.66)a,C,b,B,c,C | 30.49±2.69 (90.28)a,A,b,C,c,C | 14.25±2.79 (95.46)a,A,b,A,c,A | 4.12±1.26 (98.68)a,A,b,A,c,A | 0 (100)a,A,b,A,c,A |
| 10% BF | 296.46±1.69 (5.58) | 251.17±5.02 (20)a,C | 173.6±3.9 (44.71)a,B,b,B,c,C | 94.31±9.13 (69.96)a,A,b,B,c,B | 54.55±5.51 (82.62)a,C,b,C,c,B | 29.07±3.49 (90.74)a,A,b,C,c,C | 11.4±2 (96.36)a,A,b,A,c,A | 2.24±0.99 (99.28)a,A,b,A,c,A | 0 (100)a,A,b,A,c,A |
| 5% CF | 302.34±2.01 (3.71) | 267.26±3.41 (14.88) | 215.11±4.31 (31.49) | 136.52±6.56 (56.52)a,C | 84.24±3.34 (73.17)a,C | 46.61±2.3 (85.15)a,C | 32.02±2.76 (89.8) a,C | 20.64±1.91 (93.42) | 10.01±1.27 (96.81) |
| 10% CF | 299.28±2.61 (4.68) | 262±4.04 (16.56) | 211.16±8.81 (32.75) | 134.56±6.83 (57.14)a,B | 80.23±3.06 (74.44)a,B | 45.95±2.78 (85.36)a,C | 31.78±1.83 (89.87)a,C | 19.4±1.79 (93.82) | 9.3±1.63 (97.03) |
Notes: The data are presented as mean ± SEM (n=6) and analyzed using a one-way ANOVA with a Tukey post hoc test; aAgainst control, bAgainst 5% chloroform fraction, and cAgainst 10% chloroform fraction. Ap<0.001, Bp<0.01, Cp< 0.05.
Abbreviations: SO, Simple ointment; CF, chloroform fraction; BF, n-butanol fraction; AF, aqueous fraction; NF, Nitrofurazone ointment.