Table 3.
Cluster Analysis for iAMD Features and Spatial Delineations
| Cluster Analysis | Spatial Delineations, % | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Quadrants | Eccentricity (Ring °) | |||||||||||||||
| Clusters | Cluster Sizes (% per 69 Stimuli) | β-Coefficient (× 10−2), Mean (95% CI) | Change per −1 dB (µm) | Superior | Inferior | P | Nasal | Temporal | P | 2° | 4° | 6° | 8° | 10° | P | |
| Drusen load | 0 | 65.2% (45/69) | −0.22 (−1.02 to 0.57) | — | — | — | — | — | — | — | — | — | — | — | — | — |
| −1 | 34.8% (24/69) | −7.37 (−8.21 to −6.53)**** | 13.57 | 57 | 25 | *** | 30 | 28 | 0.79 | 80 | 0 | 5 | 45 | 63 | **** | |
| Sensitivity Differences (dB) | Effect Size (Z-Score) | |||||||||||||||
| PA | 0 | 69.6% (48/69) | −0.68 (−1.66 to 0.29) | −0.65 | — | — | — | — | — | — | — | — | — | — | — | — |
| −1 | 30.4% (21/69) | −2.23 (−3.36 to −1.1)** | −2.23 | 36 | 16 | ** | 36 | 33 | 0.72 | 100 | 88 | 40 | 5 | 0 | **** | |
| RPD | 0 | 69.6% (48/69) | −0.53 (−1.28 to 0.23) | −0.55 | — | — | — | — | — | — | — | — | — | — | — | — |
| −1 | 30.4% (21/69) | −1.07 (−2 to −0.14)** | −0.86 | 55 | 0 | **** | 43 | 23 | 0.25 | 0 | 38 | 30 | 35 | 31 | **** | |
Presentation is as in Table 2. Drusen load was measured by RPE-BM thickness (µm), and pigmentary abnormality (PA) and RPD were measured by presence or absence.
Significant differences are bolded. For multiple comparisons with significant differences (i.e., comparison between eccentricities/rings), the greatest magnitude (%) is bolded.