Table 1.
Characteristics of Patients Admitted to Shoklo Malaria Research Unit Hospitals Between 2000 and 2016 With Plasmodium vivax or Plasmodium falciparum Malaria
| Characteristic | Values by Patient Age Group, Median (Range)a | ||||||
|---|---|---|---|---|---|---|---|
| 0–28 d | 29 d to <1 y | 1–5 y | 6–10 y | 11–15 y | >15 y | Total | |
| Plasmodium vivax | |||||||
| All records, no. (%)b | 11 (4) | 45 (16) | 64 (23) | 20 (7) | 10 (4) | 128 (46) | 278 (100) |
| Male sex, no. (%)c | b5 (45) | 24 (53) | 33 (52) | 11 (55) | 6 (60) | 26 (20) | 105 (38) |
| Weight, kg | 3.4 (1.5 to 4.4) [1] | 6.5 (2.6–9.7) | 10.0 (6.3–18) [1] | 16.5 (11–28) | 32.5 (25–49) | 49 (30–71) [1] | 26 (1.5–71) [3] |
| Temperature, °C | 38.5 (36.5–39.8) | 37.8 (36.3–40.0) | 38.8 (36.5–40.7) | 38.0 (36.0–40.3) | 38.2 (37.4–40.1) | 38.0 (35.9–41.2) | 38.2 (35.9–41.2) |
| Pulse rate, beats/min | 148 (90–180) | 140 (90–188) | 131 (98–199) | 126 (84–160) | 98 (72–120) | 96 (66–148) | 119 (66–199) |
| Respirations/min | 48 (30–80) | 46 (20–76) | 39 (20–90) | 32 (22–48) | 26 (20–38) | 28 (14–52) | 32 (14–90) |
| Hematocrit, % | 36 (29–47) [2] | 27 (12–50) [2] | 30 (9–44) [2] | 29 (11–40) [4] | 33 (12–43) [2] | 33 (3–56) [8] | 32 (3–56) [20] |
| Met severe anemia definition, no. (%)c,d | 0 | 2 (4) | 2 (3) | 2 (10) | 1 (10)d | 11 (9)d | 18 (6) |
| Parasitemia, geometric mean (range), parasites/µL | 9871 (256–189 028) | 1738 (16–125 600) | 2719 (16–143 184) | 1350 (48–58 027) | 1713 (32–35 168) | 2257 (16–105 504) | 2284 (16–189 028) |
| Plasmodium falciparum | |||||||
| All records, no. (%)b | 2 (0.04) | 88 (2) | 1156 (24) | 888 (18) | 613 (13) | 2097 (43) | 4844 (100) |
| Male sex, no. (%)c | 1 (50) | 43 (49) | 615 (53) | 520 (59) | 404 (66) | 1447 (69) | 3030 (63) |
| Weight, kg | 2.5 (2.0–2.9) | 7.0 (2.6–11) | 12 (5.0–25) [1] | 19 (8–50) | 33 (16–58) [1] | 50 (20–84) [6] | 31 (2–84) [8] |
| Temperature, °C | 36.9 (35.8–38.0) | 37.8 (34.8–40.3) | 38.1 (35.5–40.9) | 38.2 (35.5–41.5) | 38.1 (35.0–41.5) | 38.0 (34.7–41.6) [3] | 38.0 (34.7–41.6) [3] |
| Heart rate, beats/min | 139 (120–158) | 140 (100–190) | 132 (60–200) | 120 (64–200) | 110 (64–160) [1] | 100 (60–160) [35] | 114 (60–200) [36] |
| Respirations/min | 39 (34–44) | 44 (26–90) | 36 (14–80) | 30 (14–60) | 28 (18–52) [1] | 26 (10–62) [35] | 28 (10–90) [36] |
| Hematocrit, % | 40 (26–54) | 26 (9–45) | 29 (6–61) [9] | 33 (9–50) [5] | 36 (8–54) [1] | 37 (5–77) [23] | 34 (5–77) [38] |
| Met severe anemia definition, no. (%)c,d | 0 | 12 (14) | 64 (6) | 18 (2) | 9 (1)d | 64 (3)d | 167 (3) |
| Parasitemia, geometric mean (range), parasites/µL | 9655 (128–728 229) | 124 644 (160–1 311 264) | 145 311 (16–1 962 375) | 208 660 (16–2 409 007) | 199 228 (32–2 101 537) | 145 580 (16–1 512 850) | 161 231 (16–2 409 007) |
Data represent median (range) unless otherwise indicated. Numbers in brackets indicate number of missing values.
Percentage of total records.
Percentage of age group.
The age threshold used is 12 years. Severe anemia is defined as hemoglobin ≤5 g/dL or hematocrit ≤15% in children <12 years old (<7 g/dL and <20%, respectively, in adults).