Table 1.

Contextualizing reporting standards of PRSs for CHD

Reporting framework for a CHD PRS
Metric	Contextual factors
• Training data set • Tuning data set • Validation data set • Heritability • SNV heritability • HR for 1 SD increase in PRS • HR for top 5th percentile vs rest • AUC and R2 for PRS • AUC and R2 for clinical risk factors +PRS • Net reclassification index • Portability to non-European ancestry individuals	• Definition of CHD • Case control ascertainment • Age dependent performance of PRS • Adjustment for relevant covariates • Inclusion of environmental factors/social determinants of health in risk models • Performance of PRS in different genetic ancestry groups and admixed individuals • QC procedures to enable PRS reporting for use in the clinical setting

HR, hazard ratio; SD, standard deviation; AUC, area under the curve; R2, liability