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. 2023 Aug 21;25(9):1332–1345. doi: 10.1038/s41556-023-01208-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a) Significant Hallmark pathways in GSEA analysis of dKO vs. WT performed in iDFs prior to (0 min) and post serum stimulation (30 min). b) Venn diagrams representing the extent of overlap between pre- and post- serum stimulation in genes up- and downregulated by macroH2A deficiency in iDFs. c) Heatmap of a subset of inflammatory genes hyper-induced by serum stimulation in the absence of macroH2A. d) Average profile of H3K27ac ChIP signal in serum-stimulated WT vs. dKO iDFs at promoters of all differentially expressed and static genes of matched expression levels following serum stimulation, n_{dKO up} = 494, n_{dKO down} = 485, n_Static = 2937. e) Average profile of macroH2A1 and macroH2A2 signal⁶² in dermal fibroblasts at genes described in (d). f) As in (d), for enhancer H3K27ac peaks differentially enriched in H3K27ac, n_{dKO up} = 1438, n_{dKO down} = 1764, n_Static = 7037. g) Average profile of macroH2A1 and macroH2A2 signal in dermal fibroblasts at regions described in (f). d-g, mean signal value and 95% CI as determined by bootstrap shown.