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. 1986 Feb;23(1):2–10. doi: 10.1136/jmg.23.1.2

Gene mapping and chromosome 19.

D J Shaw, J D Brook, A L Meredith, H G Harley, M Sarfarazi, P S Harper
PMCID: PMC1049532  PMID: 3081724

Abstract

Chromosome 19 is currently the most fully mapped of the smaller chromosomes, with about 40 loci assigned to it (HGM8). Major inherited disorders on this chromosome include myotonic dystrophy and familial hypercholesterolaemia. Other loci include five blood groups, a cluster of apolipoprotein genes, and the receptors for insulin and polio virus. A number of cloned genes and random DNA sequences identify polymorphisms which, together with blood group and other protein polymorphisms, have been used to establish a framework for ordering the loci and estimating genetic distances. Hybrid cell lines allow loci to be assigned to one of eight different regions and a detailed genetic map of the chromosome will be possible in the near future.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown S., Oie H. K., Gazdar A. F., Minna J. D., Francke U. Requirement of human chromosomes 19, 6 and possibly 3 for infection of hamster x human hybrid cells with baboon M7 type C virus. Cell. 1979 Sep;18(1):135–143. doi: 10.1016/0092-8674(79)90362-3. [DOI] [PubMed] [Google Scholar]
  2. Carle G. F., Olson M. V. Separation of chromosomal DNA molecules from yeast by orthogonal-field-alternation gel electrophoresis. Nucleic Acids Res. 1984 Jul 25;12(14):5647–5664. doi: 10.1093/nar/12.14.5647. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cook P. J., Povey S., Robson E. B. Linkage studies on peptidases A, B, C and D in man. Ann Hum Genet. 1972 Jul;36(1):89–97. doi: 10.1111/j.1469-1809.1972.tb00584.x. [DOI] [PubMed] [Google Scholar]
  4. Hamerton J. L., Douglas G. R., Gee P. A., Richardson B. J. The association of glucose phasphate isomerase expression with human chromosome 19 using somatic cell hybrids. Cytogenet Cell Genet. 1973;12(2):128–135. doi: 10.1159/000130447. [DOI] [PubMed] [Google Scholar]
  5. Humphries S. E., Berg K., Gill L., Cumming A. M., Robertson F. W., Stalenhoef A. F., Williamson R., Børresen A. L. The gene for apolipoprotein C-II is closely linked to the gene for apolipo-protein E on chromosome 19. Clin Genet. 1984 Nov;26(5):389–396. [PubMed] [Google Scholar]
  6. Ichikawa K., Crosley C. J., Culebras A., Weitkamp L. Coincidence of neurofibromatosis and myotonic dystrophy in a kindred. J Med Genet. 1981 Apr;18(2):134–138. doi: 10.1136/jmg.18.2.134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jackson C. L., Bruns G. A., Breslow J. L. Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII. Proc Natl Acad Sci U S A. 1984 May;81(10):2945–2949. doi: 10.1073/pnas.81.10.2945. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lange M., Alfi O. S. Trisomy 19 q. Ann Genet. 1976 Mar;19(1):17–21. [PubMed] [Google Scholar]
  9. Lewis W. H., Harris H. Peptidase D (prolidase) variants in man. Ann Hum Genet. 1969 May;32(4):317–322. doi: 10.1111/j.1469-1809.1969.tb00081.x. [DOI] [PubMed] [Google Scholar]
  10. MOHR J. Estimation of linkage between the Lutheran and the Lewis blood groups. Acta Pathol Microbiol Scand. 1951;29(3):339–344. doi: 10.1111/j.1699-0463.1951.tb00136.x. [DOI] [PubMed] [Google Scholar]
  11. Martiniuk F., Ellenbogen A., Hirschhorn K., Hirschhorn R. Further regional localization of the genes for human acid alpha glucosidase (GAA), peptidase D (PEPD), and alpha mannosidase B (MANB) by somatic cell hybridization. Hum Genet. 1985;69(2):109–111. doi: 10.1007/BF00293278. [DOI] [PubMed] [Google Scholar]
  12. Myklebost O., Rogne S., Olaisen B., Gedde-Dahl T., Jr, Prydz H. The locus for apolipoprotein CII is closely linked to the apolipoprotein E locus on chromosome 19 in man. Hum Genet. 1984;67(3):309–312. doi: 10.1007/BF00291359. [DOI] [PubMed] [Google Scholar]
  13. Naylor S. L., Chin W. W., Goodman H. M., Lalley P. A., Grzeschik K. H., Sakaguchi A. Y. Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse. Somatic Cell Genet. 1983 Nov;9(6):757–770. doi: 10.1007/BF01539478. [DOI] [PubMed] [Google Scholar]
  14. O'Brien T., Ball S., Sarfarazi M., Harper P. S., Robson E. B. Genetic linkage between the loci for myotonic dystrophy and peptidase D. Ann Hum Genet. 1983 May;47(Pt 2):117–121. doi: 10.1111/j.1469-1809.1983.tb00978.x. [DOI] [PubMed] [Google Scholar]
  15. Olaisen B., Teisberg P., Gedde-Dahl T., Jr The locus for apolipoprotein E (apoE) is linked to the complement component C3 (C3) locus on chromosome 19 in man. Hum Genet. 1982;62(3):233–236. doi: 10.1007/BF00333526. [DOI] [PubMed] [Google Scholar]
  16. Rettig W. J., Dracopoli N. C., Goetzger T. A., Spengler B. A., Biedler J. L., Oettgen H. F., Old L. J. Somatic cell genetic analysis of human cell surface antigens: chromosomal assignments and regulation of expression in rodent-human hybrid cells. Proc Natl Acad Sci U S A. 1984 Oct;81(20):6437–6441. doi: 10.1073/pnas.81.20.6437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Schnitzer T. J., Weiss R. A., Juricek D. K., Ruddle F. H. Use of vesicular stomatitis virus pseudotypes to map viral receptor genes: Assignment of RD114 virus receptor gene to human chromosome 19. J Virol. 1980 Aug;35(2):575–580. doi: 10.1128/jvi.35.2.575-580.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Schwartz D. C., Cantor C. R. Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis. Cell. 1984 May;37(1):67–75. doi: 10.1016/0092-8674(84)90301-5. [DOI] [PubMed] [Google Scholar]
  19. Sherman S. L., Ball S. P., Robson E. B. A genetic map of chromosome 19 based on family linkage data. Ann Hum Genet. 1985 Jul;49(Pt 3):181–187. doi: 10.1111/j.1469-1809.1985.tb01692.x. [DOI] [PubMed] [Google Scholar]
  20. Sistonen P. Linkage of the LW blood group locus with the complement C3 and Lutheran blood group loci. Ann Hum Genet. 1984 Jul;48(Pt 3):239–242. doi: 10.1111/j.1469-1809.1984.tb01020.x. [DOI] [PubMed] [Google Scholar]
  21. Thompson L. H., Mooney C. L., Burkhart-Schultz K., Carrano A. V., Siciliano M. J. Correction of a nucleotide-excision-repair mutation by human chromosome 19 in hamster-human hybrid cells. Somat Cell Mol Genet. 1985 Jan;11(1):87–92. doi: 10.1007/BF01534738. [DOI] [PubMed] [Google Scholar]
  22. Weinstock G. M., ap Rhys C., Berman M. L., Hampar B., Jackson D., Silhavy T. J., Weisemann J., Zweig M. Open reading frame expression vectors: a general method for antigen production in Escherichia coli using protein fusions to beta-galactosidase. Proc Natl Acad Sci U S A. 1983 Jul;80(14):4432–4436. doi: 10.1073/pnas.80.14.4432. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Weis J. H., Nelson D. L., Przyborski M. J., Chaplin D. D., Mulligan R. C., Housman D. E., Seidman J. G. Eukaryotic chromosome transfer: linkage of the murine major histocompatibility complex to an inserted dominant selectable marker. Proc Natl Acad Sci U S A. 1984 Aug;81(15):4879–4883. doi: 10.1073/pnas.81.15.4879. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Whitehead A. S., Solomon E., Chambers S., Bodmer W. F., Povey S., Fey G. Assignment of the structural gene for the third component of human complement to chromosome 19. Proc Natl Acad Sci U S A. 1982 Aug;79(16):5021–5025. doi: 10.1073/pnas.79.16.5021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Worwood M., Brook J. D., Cragg S. J., Hellkuhl B., Jones B. M., Perera P., Roberts S. H., Shaw D. J. Assignment of human ferritin genes to chromosomes 11 and 19q13.3----19qter. Hum Genet. 1985;69(4):371–374. doi: 10.1007/BF00291657. [DOI] [PubMed] [Google Scholar]
  26. Yamamoto T., Davis C. G., Brown M. S., Schneider W. J., Casey M. L., Goldstein J. L., Russell D. W. The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell. 1984 Nov;39(1):27–38. doi: 10.1016/0092-8674(84)90188-0. [DOI] [PubMed] [Google Scholar]
  27. Yang-Feng T. L., Francke U., Ullrich A. Gene for human insulin receptor: localization to site on chromosome 19 involved in pre-B-cell leukemia. Science. 1985 May 10;228(4700):728–731. doi: 10.1126/science.3873110. [DOI] [PubMed] [Google Scholar]

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