Table 3.
Adjusted associations to dementia/non-dementia (a), and to dementia/SCD (b).
| Unadjusted | R2* | Adjusted model 1 | Adjusted model 2 | Adjusted model 3 | Adjusted model 4 | Adjusted model 5 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | ||
| (a) | |||||||||||||
| Age | 1.11 (1.07–1.16) | < 0.001 | 0.23 | 1.03 (0.98–1.08) | 0.237 | 1.01 (0.96–1.06) | 0.707 | 1.13 (1.08–1.18) | < 0.001 | 1.06 (1.00–1.11) | 0.043 | 1.03 (0.98–1.09) | 0.205 |
| Female sex | 1.03 (0.60–1.77) | 0.909 | 0.00 | 1.04 (0.54–2.00) | 0.917 | 1.59 (0.79–3.19) | 0.193 | 1.12 (0.59–2.12) | 0.736 | 0.93 (0.47–1.84) | 0.840 | 1.38 (0.67–2.83) | 0.378 |
| Education | 0.92 (0.85–0.99) | 0.021 | 0.04 | 0.94 (0.86–1.03) | 0.156 | 0.96 (0.88–1.06) | 0.416 | 0.94 (0.86–1.02) | 0.139 | 0.93 (0.85–1.02) | 0.141 | 0.95 (0.87–1.05) | 0.319 |
| Forebrain pc/ICV | 0.68 (0.61–0.76) | < 0.001 | 0.38 | 0.71 (0.63–0.81) | < 0.001 | 0.76 (0.66–0.87) | < 0.001 | ||||||
| Hippocampi/ICV | 0.5 × 10−8 (0.3 × 10−10 − 0.1 × 10–5) | < 0.001 | 0.43 | 0.8 × 10−8 (0.1 × 10−10 − 0.5 × 10–5) | < 0.001 | 0.1 × 10−8 (1.7 × 10−10 − 0.9 × 10−4) | < 0.001 | ||||||
| BAG | 1.12 (1.06–1.19) | < 0.001 | 0.10 | 1.17 (1.09–1.26) | < 0.001 | 1.13 (1.04–1.22) | 0.003 | 1.12 (1.04–1.21) | 0.005 | ||||
| R2* | 0.40 | 0.44 | 0.36 | 0.44 | 0.48 | ||||||||
| (b) | |||||||||||||
| Age | 1.15 (1.09–1.22) | < 0.001 | 0.32 | 1.06 (0.99–1.13) | 0.096 | 1.02 (0.94–1.09) | 0.696 | 1.20 (1.12–1.29) | < 0.001 | 1.11 (1.02–1.21) | 0.013 | 1.08 (0.99–1.18) | 0.068 |
| Female sex | 1.84 (0.87–3.88) | 0.110 | 0.03 | 0.30 (0.10–0.92) | 0.034 | 1.49 (0.51–4.35) | 0.470 | 3.16 (1.04–9.59) | 0.042 | 0.22 (0.06–0.81) | 0.023 | 2.16 (0.61–7.65) | 0.232 |
| Education | 0.89 (0.91–0.98) | 0.021 | 0.06 | 0.96 (0.83–1.10) | 0.521 | 0.98 (0.86–1.12) | 0.773 | 0.94 (0.82–1.08) | 0.382 | 0.95 (0.81–1.12) | 0.575 | 0.95 (0.81–1.11) | 0.520 |
| Forebrain pc/ICV | 0.55 (0.45–0.67) | < 0.001 | 0.55 | 0.59 (0.47–0.73) | < 0.001 | 0.66 (0.52–0.84) | < 0.001 | ||||||
| Hippocampi/ICV | 0.2 × 10−11 (0.2 × 10−15–0.1 × 10−7) | < 0.001 | 0.57 | 0.1 × 10−10 (0.2 × 10−15 − 0.4 × 10−6) | < 0.001 | 0.9 × 10−8 (0.2 × 10–12-0.5 × 10−3) | 0.001 | ||||||
| BAG | 1.22 (1.12–1.34) | < 0.001 | 0.24 | 1.37 (1.21–1.55) | < 0.001 | 1.33 (1.15–1.54) | < 0.001 | 1.30 (1.13–1.49) | < 0.002 | ||||
| R2* | 0.59 | 0.58 | 0.60 | 0.69 | 0.68 | ||||||||
Logistic regression with dementia (1) versus non-dementia (0) (a), and versus SCD (0) (b), as the dependent variables.
*Nagelkerke R2.
SCD subjective cognitive decline, OR odds ratio, CI confidence interval, Forebrain pc forebrain parenchyma, ICV intracranial volume, BAG brain age gap.
Significant values are in bold.