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. 2023 Sep 11;13:14960. doi: 10.1038/s41598-023-41951-3

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ROMA analysis reveals multiple cancer-related pathways altered by SGG UCN34 in comparison to SGM. (a) Heat map view of up and downregulated pathways between three groups: SGM tumor-free, SGG UCN34 tumor-free and SGG UCN34 tumors. (b) Schematic diagram of SGG UCN34-induced activation of MAPK cascades, mTOR signaling and integrin/ILK/actin cytoskeleton pathways. ROMA pathway analysis together with IPA indicates activators of MAPK cascades by UCN34. Apart from the MAPK cascades we can point out activation of the mTOR signaling pathway as well as integrin/ILK/actin cytoskeleton signaling. ROMA: representation and quantification of module activities. Created with Biorender.com.