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. 2023 Sep 11;13:15003. doi: 10.1038/s41598-023-40940-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan-Meyer-estimates of CDA events in real-world ocrelizumab cohort. The figure depicts the probability of patients having experienced RAW or PIRA events in the observed cohort over time. CDA shows the probability of at least one of the two having occurred. CDA confirmed disability accumulation; RAW relapse-associated worsening; PIRA progression independent of relapse activity.