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. 2023 Sep 11;14:5590. doi: 10.1038/s41467-023-41318-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The t-SNE plot of MBC, postmenopausal and premenopausal FBC samples. Colors represent cell types. b Sankey diagram showing the fraction of each cell type between male and female samples. c Sankey diagram showing the fraction of each cell type between MBC, postmenopausal and premenopausal FBC samples. d Boxplot showing the percentage of cancer cells, T cells, B/Plasma cells, endothelial cells, macrophages, mast cells and myofibroblasts/CAFs in MBC (n = 6) and FBC (n = 13) samples. P value was calculated by two-sided Wilcoxon rank-sum test. e Boxplot showing the percentage of cancer cells, T cells, B/Plasma cells, endothelial cells, macrophages, mast cells and myofibroblasts/CAFs in MBC (n = 6), postmenopausal (n = 4) and premenopausal (n = 9) FBC samples. P value was calculated by two-sided Wilcoxon rank-sum test. f Boxplot showing the tumor purity and signature scores of various cell types between MBC (n = 12) and FBC (n = 710) in TCGA ER⁺ BRCA cohort. P value was calculated by two-sided Wilcoxon rank-sum test. g Boxplot showing the tumor purity and signature scores of various cell types between MBC (n = 12), postmenopausal (n = 337) and premenopausal (n = 372) FBC samples in TCGA ER⁺ BRCA cohort. P value was calculated by two-sided Wilcoxon rank-sum test. h Representative images of IHC staining detecting T cell markers CD4 and CD8 expression in MBC (n = 30) and FBC (n = 30) samples, Scale bar, 20 μm. i Boxplot indicating the IHC scores of CD4 and CD8 in 30 ER⁺ male (lightcoral) and 30 ER⁺ female (turquoise) patients (identified by the percentage of positive cells). P value was calculated by two-sided Wilcoxon rank-sum test. In d–g and i, box plots show median (center line), the upper and lower quantiles (box), and the range of the data (whiskers). Source data are provided as a Source data file.