Table 1.
Localization of the primary tumor, demographic data, histopathological data, mean Nectin-4 H-Score, and Nectin-4 expression grouped in high (H-Score 200–300), moderate (H-Score 100–199), low (H-Score 1–99), negative (H-Score = 0) for the most frequent entities
| All n = 122 |
SaDu n = 27 |
ACC n = 26 |
MuEp n = 25 |
Acin n = 13 |
EpMy n = 9 |
SecC n = 7 |
OTH n = 15 |
|
|---|---|---|---|---|---|---|---|---|
| Localization | ||||||||
| Parotid gland | 111 (91.0) | 25 (92.6) | 19 (73.1) | 25 (100.0) | 13 (100.0) | 9 (100.0) | 6 (85.7) | 14 (93.3) |
| Submandibular gland | 11 (9.0) | 2 (7.4) | 7 (26.9) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1(14.3) | 1 (6.7) |
| Demographics | ||||||||
| Female | 63 (51.6) | 6 (22.2) | 16 (61.5) | 18 (72.0) | 8 (61.5) | 3 (33.3) | 3 (42.99) | 9 (60.0) |
| Male | 59 (48.4) | 21 (77.8) | 10 (38.5) | 7 (28.0) | 5 (38.5) | 6 (66.7) | 4 (57.1) | 6 (40.0) |
| Age | 56.4 ± 17.7 | 67.7 ± 11.5 | 50.9 ± 13.4 | 44.6 ± 18.3 | 55.0 ± 19.3 | 63.9 ± 17.3 | 48.6 ± 20.0 | 66.1 ± 10.4 |
| Histopathological parameters T classification | ||||||||
| T1-2 | 59 (48.4) | 10 (37.0) | 11 (42.3) | 17 (68.0) | 6 (46.2) | 6 (66.7) | 5 (71.4) | 4 (26.7) |
| T3-4 | 59 (48.4) | 17 (63.0) | 14 (53.8) | 7 (28.0) | 7 (53.8) | 3 (33.3) | 2 (28.6) | 9 (60.0) |
| N/A | 4 (3.2) | 0 (0.0) | 1 (3.8) | 1 (4.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (13.3) |
| N classification | ||||||||
| N0 | 80 (65.6) | 4 (14.8) | 18 (69.2) | 21 (84.0) | 10 (76.9) | 9 (100.0) | 6 (85.7) | 12 (80.0) |
| N+ | 38 (31.1) | 23 (85.2) | 7 (26.9) | 3 (12.0) | 2 (15.4) | 0 (0.0) | 1 (14.3) | 2 (13.3) |
| N/A | 4 (3.3) | 0 (0.0) | 1 (3.8) | 1 (4.0) | 1 (7.7) | 0 (0.0) | 0 (0.0) | 1 (6.7) |
| Vascular invasion | ||||||||
| V0 | 99 (81.1) | 21 (77.8) | 20 (76.9) | 23 (92.0) | 12 (92.3) | 8 (88.9) | 6 (85.7) | 9 (60.0) |
| V1 | 12 (9.8) | 5 (18.5) | 1 (3.8) | 2 (8.0) | 0 (0.0) | 1 (11.1) | 1 (14.3) | 3 (20.0) |
| N/A | 11 (9.1) | 1 (3.7) | 5 (19.2) | 0 (0.0) | 1 (7.7) | 0 (0.0) | 0 (0.0) | 3 (20.0) |
| Perineural invasion | ||||||||
| Pn0 | 68 (55.7) | 5 (18.5) | 10 (38.5) | 22 (88.0) | 10 (76.9) | 8 (88.9) | 6 (85.7) | 7 (46.7) |
| Pn1 | 44 (36.1) | 22 (81.5) | 12 (46.2) | 2 (8.0) | 2 (15.4) | 0 (0.0) | 1 (14.3) | 5 (33.3) |
| N/A | 10 (8.2) | 0 (0.0) | 4 (15.4) | 1 (4.0) | 1 (7.7) | 1 (11.1) | 0 (0.0) | 3 (20.0) |
| Lymphovascular invasion | ||||||||
| L0 | 95 (77.9) | 15 (55.6) | 20 (76.9) | 24 (96.0) | 10 (76.9) | 8 (88.9) | 7 (100.0) | 11 (73.3) |
| L1 | 17 (13.9) | 11 (40.7) | 1 (3.8) | 1 (4.0) | 2 (15.4) | 1 (11.1) | 0 (0.0) | 1 (6.7) |
| N/A | 10 (8.2) | 1 (3.7) | 5 (19.2) | 0 (0.0) | 1 (7.7) | 0 (0.0) | 0 (0.0) | 3 (20.0) |
| Extracapsular extension | ||||||||
| ECE− | 94 (77.0) | 14 (51.9) | 18 (69.2) | 24 (96.0) | 11 (84.6) | 9 (100.0) | 7 (100.0) | 11 (73.3) |
| ECE+ | 19 (15.6) | 13 (48.1) | 3 (11.5) | 1 (4.0) | 1 (7.7) | 0 (0.0) | 0 (0.0) | 1 (6.7) |
| N/A | 9 (7.4) | 0 (0.0) | 5 (19.2) | 0 (0.0) | 1 (7.7) | 0 (0.0) | 0 (0.0) | 3 (20.0) |
| Grading | ||||||||
| Low | 27 (22.1) | 7 (25.9) | 1 (3.8) | 15 (60.0) | 1 (7.7) | 0 (0.0) | 2 (28.6) | 1 (6.7) |
| High/intermediate | 45 (45.1) | 17 (63.0) | 18 (69.2) | 10 (40.0) | 2 (15.4) | 1 (11.1) | 1 (14.3) | 6 (40.0) |
| N/A | 40 (32.8) | 3 (11.1) | 7 (26.9) | 0 (0.0) | 10 (76.9) | 8 (88.9) | 4 (57.1) | 8 (53.3) |
| Nectin-4 (Mean H-Score; ±) | 61.2 ± 65.7 | 78.3 ± 67.0 | 68.6 ± 75.6 | 58.1 ± 59.9 | 65.4 ± 90.6 | 78.5 ± 48.2 | 35.4 ± 34.5 | 20.9 ± 27.8 |
| Nectin-4 expression | ||||||||
| High | 6 (4.9) | 2 (7.4) | 1 (3.8) | 1 (4.0) | 2 (15.4) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Moderate | 18 (14.8) | 5 (18.5) | 7 (26.9) | 3 (12.0) | 0 (0.0) | 3 (33.3) | 0 (0.0) | 0 (0.0) |
| Low | 74 (60.7) | 16 (59.3) | 13 (50.0) | 17 (68.0) | 8 (61.5) | 6 (66.7) | 7 (100.0) | 7 (46.7) |
| Negative | 24 (19.7) | 4 (14.8) | 5 (19.2) | 4 (16.0) | 3 (23.1) | 0 (0.0) | 0 (0.0) | 8 (53.3) |
n number of patients, () percentages, ± standard deviation, MuEp Mucoepidermoid carcinoma, EpMy epithelial-myoepithelial carcinoma, Acin acinic cell carcinoma, SaDu salivary duct carcinoma, ACC adenoid cystic carcinoma, SeC secretory carcinoma, OTH others