Table 2.
Uni- and multivariate Cox-regression analysis for the prediction of overall survival.
| Parameter | univariate Cox-regression | multivariate Cox-regression | ||
|---|---|---|---|---|
| p-value | Hazard-Ratio (95% CI) | p-value | Hazard-Ratio (95% CI) | |
| CD3+HLADR+ frequency | <0.001 | 1.068 (1.037-1.099) | 0.024 | 1.054 (1.007-1.103) |
| CD3+CD8+ frequency | 0.107 | 1.022 (0.995-1.050) | 0.417 | 0.982 (0.940-1.026) |
| Age | 0.679 | 1.006 (0.979-1.033) | ||
| Sex | 0.796 | 0.971 (0.474-1.773) | ||
| UICC tumor stage | 0.432 | 1.604 (0.494-5.213) | ||
| ECOG PS | 0.012 | 1.977 (1.164-3.356) | 0.059 | 1.953 (0.976-3.907) |
| Leukocyte count | 0.521 | 1.020 (0.961-1.082) | ||
| Neutrophil count | 0.440 | 1.000 (1.000-1.000) | ||
| Lymphocyte count | 0.275 | 1.000 (0.999-1.000) | ||
| NLR | 0.166 | 1.021 (0.992-1.051) | ||
| Hemoglobin | 0.001 | 0.865 (0.794-0.943) | 0.087 | 0.915 (0.826-1.013) |
| Sodium | 0.379 | 0.969 (0.903-1.040) | ||
| Potassium | 0.250 | 0.671 (0.341-1.323) | ||
| ALT | 0.005 | 1.012 (1.004-1.020) | 0.147 | 1.014 (0.995-1.033) |
| AST | 0.023 | 1.012 (1.002-1.022) | 0.801 | 0.997 (0.977-1.018) |
| Bilirubin | 0.022 | 1.069 (1.010-1.131) | 0.232 | 1.050 (0.969-1.138) |
| Creatinine | 0.788 | 0.948 (0.643-1.397) | ||
| LDH | 0.777 | 1.000 (0.998-1.002) | ||
UICC, Union for International Cancer Control; ECOG PS, Eastern Cooperative Oncology Group performance status; NLR, neutrophil to lymphocyte ratio; ALT, alanin aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase.