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. 2023 Aug 29;14:1221493. doi: 10.3389/fimmu.2023.1221493

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Copyright © 2023 Liang, Qi, Yang, Wang, Qin, Hu, Bai, Li, Zhang and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lipids associated with the disease severity of COVID-19. (A) The raw intensity of 28 subclasses of lipids in SD vs MD; (B) The raw intensity of different degrees of unsaturation for FA, GL, GP, SP and ST classes in SD vs MD; (C) the OPLS-DA scores plot of SD vs MD. (D) the volcano plot of SD vs MD. Red dots represent the upregulated lipids (FC≥1.5, VIP≥1); blue dots represent the downregulated lipids (FC ≤ 0.67, VIP≥1); gray dots represent lipids without significant changes (0.67<FC<1.5, VIP<1). (E) The important lipids prioritized by xgboost analysis. (F) The heatmap of 21 differentially expressed lipids in SD vs MD. (G) Receiver operating characteristic (ROC) and performance of the xgboost model in the training set. (H) the raw intensity of 6 keto-PGF1α and LPC(12:0/0:0).