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. 2023 Aug 29;13:1240580. doi: 10.3389/fcimb.2023.1240580

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Copyright © 2023 Sun, Zhang, Meng, Peng, Huang, Lei, Wang, Li and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Host distribution and structural characteristics of mcr-positive plasmids The investigation of mcr-plasmids from RefSeq database via BLASTn comparison. A total of 136 complete plasmids encoding mcr were identified. Salmonella enterica and Escherichia coli are the Major hosts of positive plasmids. IncX4 and IncI2 plasmids as most abundant (approx. 30kb or 60kb), followed by IncHI2A/HI2 (220kb-270kb). The frequent detection of mcr in various plasmid backbones and bacterial isolates highlights the widespread distribution and prevalence of this resistance mechanism.