Table 2.
KEGG Analysis of DEG
| Pathway ID | Name | Count | p-value | Genes |
|---|---|---|---|---|
| 1521 | EGFR tyrosine kinase inhibitor resistance | 9 | 3.10E-10 | MET, EGFR, RPS6KB1, GSK3B, AKT1, STAT3, RAF1, BRAF, BCL2 |
| 5235 | PD-L1 expression and PD-1 checkpoint pathway cancer | 9 | 6.34E-10 | AKT1, STAT3, PTPN6, JUN, EGFR, RAF1, TRL9, NFKB1, RPS6KB1 |
| 4012 | ErbB signaling pathway | 7 | 8.41E-08 | EGFR, AKT1, RPS6KB1, GSK3B, BRAF, RAF1, JUN |
| 4330 | Notch signaling pathway | 3 | 0.0018 | ADAM17, EP300, HDAC2 |
| 4064 | NF-kappa B signaling pathway | 5 | 6.08E-05 | PTGS2, TNF, CXCL2, NFKB1, BCL2 |
| 4110 | Cell cycle | 5 | 0.00012 | EP300, HDAC2, GSK3B, CHEK1, WEE1 |
| 4115 | P53 signaling pathway | 3 | 0.004 | CHEK1, BCL2, SERPINE1 |
| 4510 | Focal adhesion | 8 | 9.50E-07 | MET, EGFR, AKT1, GSK3B, RAF1, JUN, BRAF, BCL2 |
| 4810 | Regulation of actin cytoskeleton | 4 | 0.009 | BRAF, RAF1, EGFR, CXCL2, |