Table 2.
The Genotype Frequencies of p21 and p53 Gene Variants and Their Association with Breast Cancer in Untreated BC Patients and Healthy Controls
| Gene | Genotype | Cases (n= 400) (%) |
Control (n = 400) (%) |
Odds Ratio (95% CI) |
P value | Adjusted Odds Ratio (95% CI) |
P value |
|---|---|---|---|---|---|---|---|
| p21 | Serine/Serine | 287 (71.75) | 226 (56.50) | 1 (Reference) | 1 (Reference) | ||
| codon 31 | Serine/Arginine | 95 (23.75) | 113 (28.25) | 0.66 (0.47-0.91) | <0.0003 | 0.58 (0.41-0.82) | 0.002 |
| exon-2 | Arginine/Arginine | 18 (4.50) | 61 (15.25) | 0.23 (0.13-0.40) | <0.0001 | 0.24 (0.14-0.42) | <0.001 |
| rs1801270 | |||||||
| p21 | CC/CC | 279 (69.75) | 309 (77.25) | 1 (Reference) | 1 (Reference) | ||
| exon-3 | CC/TT | 114 (28.50) | 84 (21.00) | 1.50 (1.08- 2.08) | 0.01 | 1.64 (1.16-2.32) | 0.005 |
| rs1059234 | TT/TT | 7 (1.72) | 7 (01.75) | 1.1 (0.38- 3.19) | 0.85 | 1.50 (0.48-4.70) | 0.485 |
| p53 | Arginine/Arginine | 80 (20.00) | 95 (23.75) | 1 (Reference) | 1 (Reference) | ||
| Codon72 | Arginine / Proline | 214 (53.50) | 213 (53.25) | 1.19 (0.83-1.69) | 0.33 | 1.15 (0.80-1.65) | 0.45 |
| Exon-4 | Proline/Proline | 106 (26.50) | 92 (23.00) | 1.36 (0.90-2.05) | 0.13 | 1.32 (0.87-2.00) | 0.19 |
| rs1042522 | |||||||
| p53 | Arginine/Arginine | 316 (79.00) | 334 (83.50) | 1 (Reference) | 1 (Reference) | ||
| Codon249 | Arginine/Serine | 0 | 0 | ||||
| Exon-7 | Serine / Serine | 84 (21.00) | 66 (16.50) | 1.38 (0.97-1.97) | 0.07 | 1.32 (0.92-1.9) | 0.137 |
| rs28934571 |
Significance p< 0.005; OR, Odds ratio; CI, Confidence Interval