Table 3.
Association between Breast Cancer Risk and the Single Nucleotide Polymorphism Variant of p53 and p21 Genes in the Recessive Model
| Genes | Genotype | Cases | Control | OR (95% CI) | p value | ||
|---|---|---|---|---|---|---|---|
| (n= 400) | (%) | (n= 400) | (%) | ||||
| p21 | Ser/Ser + Ser/Arg | 382 | 95.50 | 339 | 84.75 | 1 (Reference) | |
| rs1801270 | Arg/Arg | 18 | 4.50 | 61 | 15.25 | 0.26 (0.15-0.45) | <0.0001 |
| p21 | CC/CC+CC/CT | 393 | 98.25 | 393 | 98.25 | 1 (Reference) | |
| rs1059234 | TT/TT | 7 | 1.75 | 7 | 1.75 | 1.00 (0.34-2.87) | 1.00 |
| p53 | Arg/Arg+ Arg /Pro | 294 | 73.50 | 308 | 77.00 | 1 (Reference) | |
| rs1042522 | Pro/Pro | 106 | 26.50 | 92 | 23.00 | 1.20 (0.87-1.66) | 0.25 |
| p53 | Arg/Arg+Arg/Ser | 316 | 79.00 | 334 | 83.50 | 1 (Reference) | |
| rs28934571 | Ser/Ser | 84 | 21.00 | 66 | 16.50 | 1.38 (0.97-1.97) | 0.07 |
Significance p< 0.005; OR, Odds ratio; CI, Confidence Interval