Table 4.
Association between Breast Cancer Risk and the Single Nucleotide Polymorphism Variant of p53 and p21 Genes in the Dominant Model
| Genes | Genotype | Cases | Caontrols | OR (95% CI) | P value | ||
|---|---|---|---|---|---|---|---|
| (n= 400) | (%) | (n= 400) | (%) | ||||
| p21 | Ser/Ser | 287 | 71.75 | 226 | 56.50 | 1 (Reference | |
| rs1801270 | Ser/Arg + Arg/Arg | 113 | 28.25 | 174 | 43.50 | 0.51 (0.38-0.68) | <0.0001 |
| p21 | CC/CC | 279 | 69.75 | 309 | 77.25 | 1 (Reference) | |
| rs1059234 | CC/CT + TT/TT | 121 | 30.25 | 91 | 22.75 | 1.47 (1.07-2.02) | 0.01 |
| p53 | Arg/Arg | 80 | 20.00 | 95 | 23.75 | 1 (Reference) | |
| rs1042522 | Arg/Pro +Pro/Pro | 320 | 80.00 | 305 | 76.25 | 0.80 (0.57-1.12) | 0.2 |
| p53 | Arg/Arg | 316 | 79.00 | 334 | 83.50 | 1 (Reference) | |
| rs28934571 | Arg/Ser + Ser/Ser | 84 | 21.00 | 66 | 16.50 | 1.38 (0.97-1.97) | 0.07 |
Significance p< 0.005; OR, Odds ratio; CI, Confidence Interval