Table 5.
Association between p21 codon 31 of exon 2, exon3 Genotypes and Clinicopathologic Characteristics among Breast Cancer Cases
| Variables | Total (n) | p21 codon -31 (Genotypes) | p21 exon-3 (Genotypes) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Ser/Ser | Ser/Arg | Arg/Arg | Χ2 | CC | C/A | AA | Χ2 | ||
| (287) | (95) | (18) | (p value) | (279) | (114) | (7) | (p value) | ||
| Age group (yrs) | |||||||||
| ≤40 | 78 | 54 (18.82) | 22 (23.16) | 2 (11.11) | 1.238 | 53 (19.00) | 25 (21.93) | 0 | 2.16 |
| >40 | 322 | 233 (81.18) | 73 (76.84) | 16 (88.89) | 0.53 | 226 (81.00) | 89 (78.07) | 7 (100.0) | 0.33 |
| ER status | |||||||||
| Positive | 218 | 158 (55.05) | 52 (54.74) | 8 (44.44) | 0.154 | 154 (55.20) | 61 (53.51) | 3 (42.86) | 0.66 |
| Negative | 182 | 129 (44.95) | 43 (45.26) | 10 (55.56) | 0.92 | 125 (44.80) | 53 (46.49) | 4 (57.14) | 0.71 |
| PR status | |||||||||
| Positive | 197 | 141 (49.13) | 47 (49.47) | 9 (50.00) | 0.002 | 141 (50.54) | 53 (46.49) | 3 (42.86) | 0.75 |
| Negative | 203 | 146 (50.87) | 48 (50.53) | 9 (50.00) | 0.99 | 138 (49.46) | 61 (53.51) | 4 (57.14) | 0.68 |
| Her2-neu status | |||||||||
| Positive | 57 | 41 (14.29) | 14 (14.74) | 2 (11.11) | 0.115 | 204 (73.11) | 13 (11.40) | 1 (14.29) | 0.74 |
| Negative | 343 | 246 (85.71) | 81 (85.26) | 16 (88.89) | 0.94 | 75 (26.89) | 101 (88.60) | 6 (85.71) | 0.69 |
| Clinical stage | |||||||||
| I | 48 | 39 (13.59) | 9 (9.47) | 0 | 14.24 | 37 (13.26) | 11 (9.65) | 0 | 11.53 |
| II | 147 | 104 (36.23) | 41(43.16) | 2 (11.11) | 0.025 | 103 (36.92) | 43 (37.72) | 1 (14.28) | 0.08 |
| III | 120 | 87 (30.31) | 26 (27.37) | 7 (38.89) | 89 (31.90) | 28 (24.56) | 3 (42.86) | ||
| IV | 85 | 57 (19.87) | 19 (20.00) | 9 (50.00) | 50 (17.92) | 32 ( 28.07) | 3 (42.86) | ||
| Tumor localization | |||||||||
| Right breast | 185 | 134 (46.69) | 43 (45.26) | 8 (44.44) | 0.841 | 131 (46.95) | 51 (44.74) | 3 (42.86) | 28.54 |
| Left breast | 213 | 152 (52.96) | 51 (53.68) | 10 (55.56) | 0.93 | 148 (53.05) | 62 (54.39) | 3 (42.86) | <0.001 |
| Right + Left breast | 2 | 1 (0.35) | 1 (1.06) | 0 | 0 | 1 (0.87) | 1 (14.28) | ||
ER, Estrogen Receptor; PR, Progesterone Receptor; Significance p< 0.005