Table 6.
Association between p53 codon 72 of exon 4 and codon 249 of exon 7 Genotypes and Clinicopathologic Characteristics among Breast Cancer Cases
| Variables | Total (n) | P53 codon -72 (Genotypes) | P53 codon -249 (Genotypes) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Arg/Arg | Arg/Pro | Pro/Pro | Χ2 | Arg/Arg | Arg/Ser | Ser/Ser | Χ2 | ||
| (106) | (214) | (80) | (p value) | (316) | 0 | (84) | (p value) | ||
| Age group (yrs) | |||||||||
| ≤40 | 78 | 26 (24.53) | 38 (17.76) | 14 (17.50) | 1.55 | 69 (21.84) | 0 | 9 (10.71) | 5.22 |
| >40 | 322 | 80 (75.47) | 176 (82.24) | 66 (82.50) | 0.46 | 247 (78.16) | 0 | 75 (89.29) | 0.02 |
| ER status | |||||||||
| Positive | 218 | 64 (60.38) | 111 (51.87) | 43 (53.75) | 2.09 | 179 (56.65) | 0 | 39 (46.43) | 2.79 |
| Negative | 182 | 42 (39.62) | 103 (48.13) | 37 (46.25) | 0.35 | 137 (43.35) | 0 | 45 (53.57) | 0.09 |
| PR status | |||||||||
| Positive | 197 | 60 (56.60) | 128 (59.81) | 39 (48.75) | 3.05 | 160 (50.63) | 0 | 37 (44.05) | 1.26 |
| Negative | 203 | 46 (43.40) | 86 (40.19) | 41 (51.25) | 0.27 | 156 (49.37) | 0 | 47 (55.95) | 0.65 |
| Her2-neu status | |||||||||
| Positive | 57 | 20 (18.87) | 21 (9.81) | 16 (20.00) | 7.69 | 41 (12.97) | 0 | 16 (19.05) | 2.51 |
| Negative | 343 | 86 (81.13) | 193 (90.19) | 64 (80.00) | 0.02 | 275 (87.03) | 0 | 68 (80.95) | 0.11 |
| Clinical stage | |||||||||
| I | 48 | 15 (14.15) | 25 (11.68) | 8 (10.00) | 3.3 | 37 (11.71) | 0 | 11 (13.10) | 2.71 |
| II | 147 | 43 (40.57) | 73 (34.11) | 31 (38.75) | 0.76 | 120 (37.97) | 0 | 27 (32.14) | 0.43 |
| III | 120 | 25 (23.58) | 69 (32.24) | 26 (32.50) | 97 (30.70) | 0 | 23 (27.38) | ||
| IV | 85 | 23 (21.70) | 47 (21.97) | 15 (18.75) | 62 (19.62) | 0 | 23 (27.38) | ||
| Tumor localization | |||||||||
| Right breast | 185 | 49 (46.23) | 96 (44.86) | 40 (50.00) | 6.7 | 148 (46.84) | 0 | 37 (44.05) | 1.1 |
| Left breast | 213 | 56 (52.83) | 117 (54.67) | 40 (50.00) | 0.15 | 167 (52.85) | 0 | 46 (54.76) | 0.57 |
| Right + Left breast | 2 | 1 (0.94) | 1 (0.47) | 0 | 1 (0.31) | 0 | 1 (1.19) | ||
ER, Estrogen Receptor; PR, Progesterone Receptor; Significance p< 0.005