Table 7.
Association of p53 and p21 Gene Variants with Demographic Variables Including Age of Cancer Occurrence, Age at First Pregnancy and Tobacco Smoking in Breast Cancer Cases and Control Group from Population of Maharashtra
| Gene | Genotype | Age (yrs) | Age (yrs) @ 1st pregnancy | Tobacco status | |||
|---|---|---|---|---|---|---|---|
| (Cases/Control) | (Cases/Control) | (Cases/Control) | |||||
| ≤ 40 | > 40 | ≤ 20 | > 20 | Users | Non-Users | ||
| N=78/207 | N=322/193 | N=218/183 | N=182/217 | N=219/113 | N=181/287 | ||
| p21 | C/C | 54/120 | 233/106 | 157/93 | 130/133 | 156/68 | 131/158 |
| codon 31 | C/A + A/A | 24/87 | 89/87 | 61/90 | 52/84 | 63/45 | 50/129 |
| exon-2 | OR (95% CI) | 0.61 (0.35-1.06) | 0.46 (0.32-0.67) | 0.40 (0.26-0.60) | 0.63 (0.41-0.96) | 0.61 (0.37-0.98) | 0.46 (0.31-0.69) |
| C>A | p value | 0.08 | 0.0001 | <0.0001 | 0.03 | 0.04 | 0.002 |
| rs1801270 | |||||||
| p21 | C/C | 53/165 | 226/144 | 152/139 | 127/170 | 149/79 | 130/230 |
| exon-3 | C/T + T/T | 25/42 | 96/49 | 66/44 | 55/47 | 70/34 | 51/57 |
| C>T | OR (95% CI) | 1.85 (1.03-3.32) | 0.98 (0.65-1.49) | 1.37 (0.87-2.14) | 1.56 (0.99-2.46) | 1.09 (0.66-1.78) | 1.58 (1.02-2.44) |
| rs1059234 | p value | 0.01 | 0.95 | 0.16 | 0.05 | 0.72 | 0.03 |
| Codon72 | G/G | 26/40 | 80/52 | 55/50 | 51/42 | 57/27 | 49/65 |
| Exon-4 | G/C+C/C | 52/167 | 242/141 | 163/133 | 131/175 | 162/86 | 132/222 |
| G>C | OR(95% CI) | 0.47 (0.26-0.85) | 1.11 (0.74-1.67) | 1.11 (0.71-1.74) | 0.61 (0.38-0.98) | 0.89 (0.52-1.51) | 0.78 (0.51-1.21) |
| rs1042522 | p value | 0.01 | 0.59 | 0.63 | 0.04 | 0.67 | 0.27 |
| p53 | G/G | 69/178 | 247/156 | 172/147 | 144/187 | 177/93 | 139/241 |
| Codon249 | G/T + T/T | 29-Sep | 75/37 | 46/36 | 38/30 | 42/20 | 42/46 |
| Exon-7 | OR (95% CI) | 0.80 (0.36-1.77) | 1.28 (0.82-1.99) | 1.09 (0.67-1.78) | 1.64 (0.97-2.78) | 1.10 (0.61-1.98) | 1.58 (0.99-2.52) |
| G>T | pvalue | 0.58 | 0.27 | 0.72 | 0.06 | 0.74 | 0.05 |
| rs28934571 | |||||||
Significance p= 0.005; OR, Odds ratio; CI, Confidence Interval.