Table 1. Baseline Characteristics for Infants Contributing Data to the Follow-Up Study.
| No. (%)a | ||
|---|---|---|
| Minimally invasive surfactant therapy (n = 224) | Control treatment (n = 229) | |
| Demographic characteristics | ||
| Gestation, median (IQR), wk | 27.3 (26.3-28.1) | 27.3 (26.4-28.0) |
| Birth weight, median (IQR), g | 932 (780-1065) | 905 (777-1070) |
| Birth weight <10th centile | 32 (14.3) | 31 (13.5) |
| Sex | ||
| Female | 108 (48.2) | 120 (52.4) |
| Male | 116 (51.8) | 109 (47.6) |
| Plurality, birth order | ||
| Singleton | 140 (62.5) | 158 (69.0) |
| First of multiples | 40 (17.8) | 30 (13.1) |
| Second or subsequent multiple | 44 (19.6) | 41 (17.9) |
| Peripartum details | ||
| Exposure to antenatal glucocorticoids | ||
| ≥2 Doses prior to delivery | 144 (64.3) | 162 (70.7) |
| 1 Dose prior to delivery | 60 (26.8) | 48 (21.0) |
| None | 20 (8.9) | 19 (8.3) |
| Delivery mode | ||
| Vaginal delivery | 40 (17.9) | 49 (21.4) |
| Cesarean delivery with labor | 91 (40.6) | 75 (32.8) |
| Cesarean delivery, no labor | 93 (41.5) | 105 (45.9) |
| Apgar scoreb | ||
| At 5 min, median (IQR) | 8 (7-9) | 8 (7-9) |
| <7 at 5 min | 28 (12.5) | 30 (13.1) |
| Clinical state at randomization | ||
| Age, median (IQR), h | 2.7 (1.6-4.0) | 2.6 (1.7-3.6) |
| CPAP level at randomization, median (IQR), cm H2O | 7 (6-8) | 7 (6-8) |
| Fio2 at randomization, median (IQR) | 0.35 (0.30-0.40) | 0.35 (0.30-0.40) |
| Fio2 ≤0.35 | 141 (62.9) | 141 (61.6) |
| Data gathered after first hospital discharge | ||
| Oxygen therapy at home, No./total (%) | 24/195 (12.3) | 46/205 (22.4) |
| Immunized against, No./total (%) | ||
| RSV | 119/175 (68.0) | 128/185 (69.2) |
| Influenza | 91/173 (52.6) | 104/184 (56.5) |
| Family history of asthma (in parents or siblings), No./total (%) | 50/177 (28.2) | 53/188 (28.2) |
| Corrected age at 2 y assessment, median (IQR), y | 2.05 (2.00-2.15) | 2.04 (2.00-2.18) |
Abbreviations: CPAP, continuous positive airway pressure; Fio2, fraction of inspired oxygen; RSV, respiratory syncytial virus.
a
Complete data available for all prerandomization and perirandomization variables; postdischarge data shown for survivors with follow-up data available.
b
Indicates success of transition at birth. The score range is 0 to 10. A score of 0 to 2 is given for each of the following: heart rate, respiratory effort, reflex irritability, muscle tone, and skin color. An Apgar score of 7 or greater at 5 minutes after birth generally indicates a satisfactory transition for a preterm infant.