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. Author manuscript; available in PMC: 2023 Sep 12.
Published in final edited form as: Neurochem Int. 2023 Feb 8;164:105506. doi: 10.1016/j.neuint.2023.105506

Fig. 6. Effect of 12(13)-EpOME on the dendritic arborization of primary rat cortical neurons.

Fig. 6.

Dendritic morphology was quantified in DIV 9 cortical neurons following a 48 h exposure to varying concentratons of 12(13)-EpOME. (A) Total dendritic length, (B) number of dendritic branch points, and (C) number of dendritic tips per neuron are plotted as the mean ± SD (n = 8–9 wells per treatment per sex from three independent dissections). (D,E) Sholl plots (left) showing the mean (n = 8–9 wells per treatment per sex from three independent dissections) number of dendritic intersections with Sholl rings at different distances from the cell body and bar graphs showing the mean ± SD (n = 8–9 wells per treatment per sex from three independent dissections) of the area under the curve (AUC) were determined independently for male (D) and female (E) cortical neurons. Data from individual neurons (40–80 neurons per well of 2–3 wells per dissection) were averaged within each independent dissection. *Significantly different from vehicle control at p < 0.05 as determined by one-way ANOVA followed by Dunnett’s multiple comparison post hoc test. #Significantly different from vehicle control at p < 0.05 as determined using unpaired t-test.